Science 319 (5866): 1104-1107

Copyright © 2008 by the American Association for the Advancement of Science

Spine-Type-Specific Recruitment of Newly Synthesized AMPA Receptors with Learning

Naoki Matsuo,^* Leon Reijmers, Mark Mayford^*

Abstract: The stabilization of long-term memories requires de novo protein synthesis. How can proteins, synthesized in the soma, act on specific synapses that participate in a given memory? We studied the dynamics of newly synthesized AMPA-type glutamate receptors (AMPARs) induced with learning using transgenic mice expressing the GluR1 subunit fused to green fluorescent protein (GFP-GluR1) under control of the c-fos promoter. We found learning-associated recruitment of newly synthesized GFP-GluR1 selectively to mushroom-type spines in adult hippocampal CA1 neurons 24 hours after fear conditioning. Our results are consistent with a "synaptic tagging" model to allow activated synapses to subsequently capture newly synthesized receptor and also demonstrate a critical functional distinction in the mushroom spines with learning.

Department of Cell Biology and Institute for Childhood and Neglected Diseases, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Present address: Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-1192, Japan.

^* To whom correspondence should be addressed. E-mail: n-matsuo{at}fujita-hu.ac.jp (N.M.); mmayford{at}scripps.edu (M.M.)

Experience-Dependent, Rapid Structural Changes in Hippocampal Pyramidal Cell Spines.

T. Kitanishi, Y. Ikegaya, N. Matsuki, and M. K. Yamada (2009)
Cereb Cortex 19, 2572-2578
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Behavioral tagging is a general mechanism of long-term memory formation.

F. Ballarini, D. Moncada, M. C. Martinez, N. Alen, and H. Viola (2009)
PNAS 106, 14599-14604
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Connectivity Patterns Revealed by Mapping of Active Inputs on Dendrites of Thalamorecipient Neurons in the Auditory Cortex.

R. J. Richardson, J. A. Blundon, I. T. Bayazitov, and S. S. Zakharenko (2009)
J. Neurosci. 29, 6406-6417
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Input-Specific Spine Entry of Soma-Derived Vesl-1S Protein Conforms to Synaptic Tagging.

D. Okada, F. Ozawa, and K. Inokuchi (2009)
Science 324, 904-909
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Segregated Populations of Hippocampal Principal CA1 Neurons Mediating Conditioning and Extinction of Contextual Fear.

N. C. Tronson, C. Schrick, Y. F. Guzman, K. H. Huh, D. P. Srivastava, P. Penzes, A. L. Guedea, C. Gao, and J. Radulovic (2009)
J. Neurosci. 29, 3387-3394
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Environmental Enrichment Restores Memory Functioning in Mice with Impaired IL-1 Signaling via Reinstatement of Long-Term Potentiation and Spine Size Enlargement.

I. Goshen, A. Avital, T. Kreisel, T. Licht, M. Segal, and R. Yirmiya (2009)
J. Neurosci. 29, 3395-3403
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Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors.

Y. Shinohara, H. Hirase, M. Watanabe, M. Itakura, M. Takahashi, and R. Shigemoto (2008)
PNAS 105, 19498-19503
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Ras Signaling Mechanisms Underlying Impaired GluR1-Dependent Plasticity Associated with Fragile X Syndrome.

H. Hu, Y. Qin, G. Bochorishvili, Y. Zhu, L. van Aelst, and J. J. Zhu (2008)
J. Neurosci. 28, 7847-7862
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Highlights From The Literature.

(2008)
Physiology 23, 128-130
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