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Science 319 (5867): 1241-1244

Copyright © 2008 by the American Association for the Advancement of Science

Local Positive Feedback Regulation Determines Cell Shape in Root Hair Cells

Seiji Takeda,1 Catherine Gapper,1 Hidetaka Kaya,2,3 Elizabeth Bell,1 Kazuyuki Kuchitsu,2,3 Liam Dolan1*

Abstract: The specification and maintenance of growth sites are tightly regulated during cell morphogenesis in all organisms. ROOT HAIR DEFECTIVE 2 reduced nicotinamide adenine dinucleotide phosphate (RHD2 NADPH) oxidase–derived reactive oxygen species (ROS) stimulate a Ca2+ influx into the cytoplasm that is required for root hair growth in Arabidopsis thaliana. We found that Ca2+, in turn, activated the RHD2 NADPH oxidase to produce ROS at the growing point in the root hair. Together, these components could establish a means of positive feedback regulation that maintains an active growth site in expanding root hair cells. Because the location and stability of growth sites predict the ultimate form of a plant cell, our findings demonstrate how a positive feedback mechanism involving RHD2, ROS, and Ca2+ can determine cell shape.

1 Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK.
2 Genome and Drug Research Center, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.
3 Department of Applied Biological Science, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan.

* To whom correspondence should be addressed. E-mail: liam.dolan{at}bbsrc.ac.uk

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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)