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Science 319 (5871): 1787-1789

Copyright © 2008 by the American Association for the Advancement of Science

The Eukaryotic Genome as an RNA Machine

Paulo P. Amaral, Marcel E. Dinger, Tim R. Mercer, John S. Mattick*

Abstract: The past few years have revealed that the genomes of all studied eukaryotes are almost entirely transcribed, generating an enormous number of non–protein-coding RNAs (ncRNAs). In parallel, it is increasingly evident that many of these RNAs have regulatory functions. Here, we highlight recent advances that illustrate the diversity of ncRNA control of genome dynamics, cell biology, and developmental programming.

Institute for Molecular Bioscience, University of Queensland, St. Lucia QLD 4072, Australia.

* To whom correspondence should be addressed. E-mail: j.mattick{at}

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