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Science 319 (5871): 1793-1794

Copyright © 2008 by the American Association for the Advancement of Science

Gene Regulation in the Third Dimension

Job Dekker*

Abstract: Analysis of the spatial organization of chromosomes reveals complex three-dimensional networks of chromosomal interactions. These interactions affect gene expression at multiple levels, including long-range control by distant enhancers and repressors, coordinated expression of genes, and modification of epigenetic states. Major challenges now include deciphering the mechanisms by which loci come together and understanding the functional consequences of these often transient associations.

Program in Gene Function and Expression and Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605–0103, USA.

* To whom correspondence should be addressed. E-mail: Job.Dekker{at}umassmed.edu

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