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Science 319 (5871): 1795-1797

Copyright © 2008 by the American Association for the Advancement of Science

Complex Riboswitches

Ronald R. Breaker

Abstract: Using simple biochemical tricks, metabolite-binding riboswitches take on gene control functions that have long been thought to be the work of protein factors. Although modern riboswitches might be the last holdouts of primitive genetic elements, some are capable of sensory and regulatory feats that are competitive with their protein counterparts.

Department of Molecular, Cellular and Developmental Biology, Department of Molecular Biophysics and Biochemistry, and Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA. E-mail: ronald.breaker{at}yale.edu

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The Riboswitch Regulates a Thiamine Pyrophosphate ABC Transporter of the Oral Spirochete Treponema denticola.
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A variant riboswitch aptamer class for S-adenosylmethionine common in marine bacteria.
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A Binding Resolution.
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Plant Physiology 150, 3-5
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Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP.
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Science 321, 411-413
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