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Science 319 (5871): 1795-1797

Copyright © 2008 by the American Association for the Advancement of Science

Complex Riboswitches

Ronald R. Breaker

Abstract: Using simple biochemical tricks, metabolite-binding riboswitches take on gene control functions that have long been thought to be the work of protein factors. Although modern riboswitches might be the last holdouts of primitive genetic elements, some are capable of sensory and regulatory feats that are competitive with their protein counterparts.

Department of Molecular, Cellular and Developmental Biology, Department of Molecular Biophysics and Biochemistry, and Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA. E-mail: ronald.breaker{at}

Structural determinants for ligand capture by a class II preQ1 riboswitch.
M. Kang, C. D. Eichhorn, and J. Feigon (2014)
PNAS 111, E663-E671
   Abstract »    Full Text »    PDF »
RNA nanotechnology for computer design and in vivo computation.
M. Qiu, E. Khisamutdinov, Z. Zhao, C. Pan, J.-W. Choi, N. B. Leontis, and P. Guo (2013)
Phil Trans R Soc A 371, 20120310
   Abstract »    Full Text »    PDF »
Loop-loop interaction in an adenine-sensing riboswitch: A molecular dynamics study.
O. Allner, L. Nilsson, and A. Villa (2013)
RNA 19, 916-926
   Abstract »    Full Text »    PDF »
Eukaryotic TPP riboswitch regulation of alternative splicing involving long-distance base pairing.
S. Li and R. R. Breaker (2013)
Nucleic Acids Res. 41, 3022-3031
   Abstract »    Full Text »    PDF »
Global or local? Predicting secondary structure and accessibility in mRNAs.
S. J. Lange, D. Maticzka, M. Mohl, J. N. Gagnon, C. M. Brown, and R. Backofen (2012)
Nucleic Acids Res. 40, 5215-5226
   Abstract »    Full Text »    PDF »
Multiple conformations of SAM-II riboswitch detected with SAXS and NMR spectroscopy.
B. Chen, X. Zuo, Y.-X. Wang, and T. K. Dayie (2012)
Nucleic Acids Res. 40, 3117-3130
   Abstract »    Full Text »    PDF »
The Riboswitch Regulates a Thiamine Pyrophosphate ABC Transporter of the Oral Spirochete Treponema denticola.
J. Bian, H. Shen, Y. Tu, A. Yu, and C. Li (2011)
J. Bacteriol. 193, 3912-3922
   Abstract »    Full Text »    PDF »
Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems.
Y. Y. Chen, M. C. Jensen, and C. D. Smolke (2010)
PNAS 107, 8531-8536
   Abstract »    Full Text »    PDF »
A variant riboswitch aptamer class for S-adenosylmethionine common in marine bacteria.
E. Poiata, M. M. Meyer, T. D. Ames, and R. R. Breaker (2009)
RNA 15, 2046-2056
   Abstract »    Full Text »    PDF »
A Binding Resolution.
A. M. Jones and M. R. Sussman (2009)
Plant Physiology 150, 3-5
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Riboswitches in Eubacteria Sense the Second Messenger Cyclic Di-GMP.
N. Sudarsan, E. R. Lee, Z. Weinberg, R. H. Moy, J. N. Kim, K. H. Link, and R. R. Breaker (2008)
Science 321, 411-413
   Abstract »    Full Text »    PDF »

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