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Copyright © 2008 by the American Association for the Advancement of Science
An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models
Lyudmila G. Burdelya,1*
Vadim I. Krivokrysenko,2*
Thomas C. Tallant,3
Evguenia Strom,2
Anatoly S. Gleiberman,2
Damodar Gupta,1
Oleg V. Kurnasov,4
Farrel L. Fort,2
Andrei L. Osterman,4
Joseph A. DiDonato,3
Elena Feinstein,2 Abstract:
The toxicity of ionizing radiation is associated with massive apoptosis in radiosensitive organs. Here, we investigate whether a drug that activates a signaling mechanism used by tumor cells to suppress apoptosis can protect healthy cells from the harmful effects of radiation. We studied CBLB502, a polypeptide drug derived from Salmonella flagellin that binds to Toll-like receptor 5 (TLR5) and activates nuclear factor–
1 Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
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Science Signaling. ISSN 1937-9145 (pre-2008: Science's STKE. ISSN 1525-8882)