Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 320 (5875): 535-538

Copyright © 2008 by the American Association for the Advancement of Science

Encoding Gender and Individual Information in the Mouse Vomeronasal Organ

Jie He,1 Limei Ma,1 SangSeong Kim,1 Junichi Nakai,2 C. Ron Yu1*

Abstract: The mammalian vomeronasal organ detects complex chemical signals that convey information about gender, strain, and the social and reproductive status of an individual. How these signals are encoded is poorly understood. We developed transgenic mice expressing the calcium indicator G-CaMP2 and analyzed population responses of vomeronasal neurons to urine from individual animals. A substantial portion of cells was activated by either male or female urine, but only a small population of cells responded exclusively to gender-specific cues shared across strains and individuals. Female cues activated more cells and were subject to more complex hormonal regulations than male cues. In contrast to gender, strain and individual information was encoded by the combinatorial activation of neurons such that urine from different individuals activated distinctive cell populations.

1 Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.
2 Laboratory for Memory and Learning, RIKEN Brain Science Institute, 2-1 Hirosawa, Wakoshi, Saitama, 351-0198, Japan.

* To whom correspondence should be addressed: cry{at}stowers-institute.org


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Evolutionary Characterization of a V1R Subfamily Unique to Strepsirrhine Primates.
A. D. Yoder, L. M. Chan, M. dos Reis, P. A. Larsen, C. R. Campbell, R. Rasoloarison, M. Barrett, C. Roos, P. Kappeler, J. Bielawski, et al. (2014)
Genome Biol Evol 6, 213-227
   Abstract »    Full Text »    PDF »
Reliable Sex and Strain Discrimination in the Mouse Vomeronasal Organ and Accessory Olfactory Bulb.
I. I. Tolokh, X. Fu, and T. E. Holy (2013)
J. Neurosci. 33, 13903-13913
   Abstract »    Full Text »    PDF »
Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling.
Y. Ahn, C. Sims, J. M. Logue, S. D. Weatherbee, and R. Krumlauf (2013)
Development 140, 583-593
   Abstract »    Full Text »    PDF »
Pervasive and Ongoing Positive Selection in the Vomeronasal-1 Receptor (V1R) Repertoire of Mouse Lemurs.
P. Hohenbrink, U. Radespiel, and N. I. Mundy (2012)
Mol. Biol. Evol. 29, 3807-3816
   Abstract »    Full Text »    PDF »
Activity Regulates Functional Connectivity from the Vomeronasal Organ to the Accessory Olfactory Bulb.
K. R. Hovis, R. Ramnath, J. E. Dahlen, A. L. Romanova, G. LaRocca, M. E. Bier, and N. N. Urban (2012)
J. Neurosci. 32, 7907-7916
   Abstract »    Full Text »    PDF »
Distributed representation of chemical features and tunotopic organization of glomeruli in the mouse olfactory bulb.
L. Ma, Q. Qiu, S. Gradwohl, A. Scott, E. Q. Yu, R. Alexander, W. Wiegraebe, and C. R. Yu (2012)
PNAS 109, 5481-5486
   Abstract »    Full Text »    PDF »
Organization of Vomeronasal Sensory Coding Revealed by Fast Volumetric Calcium Imaging.
D. Turaga and T. E. Holy (2012)
J. Neurosci. 32, 1612-1621
   Abstract »    Full Text »    PDF »
Detection and avoidance of a carnivore odor by prey.
D. M. Ferrero, J. K. Lemon, D. Fluegge, S. L. Pashkovski, W. J. Korzan, S. R. Datta, M. Spehr, M. Fendt, and S. D. Liberles (2011)
PNAS 108, 11235-11240
   Abstract »    Full Text »    PDF »
Chemosensory burst coding by mouse vomeronasal sensory neurons.
H. A. Arnson and T. E. Holy (2011)
J Neurophysiol 106, 409-420
   Abstract »    Full Text »    PDF »
Distinct Signals Conveyed by Pheromone Concentrations to the Mouse Vomeronasal Organ.
J. He, L. Ma, S. Kim, J. Schwartz, M. Santilli, C. Wood, M. H. Durnin, and C. R. Yu (2010)
J. Neurosci. 30, 7473-7483
   Abstract »    Full Text »    PDF »
In vivo vomeronasal stimulation reveals sensory encoding of conspecific and allospecific cues by the mouse accessory olfactory bulb.
Y. Ben-Shaul, L. C. Katz, R. Mooney, and C. Dulac (2010)
PNAS 107, 5172-5177
   Abstract »    Full Text »    PDF »
From Pheromones to Behavior.
R. Tirindelli, M. Dibattista, S. Pifferi, and A. Menini (2009)
Physiol Rev 89, 921-956
   Abstract »    Full Text »    PDF »
Ca2+-Calmodulin Feedback Mediates Sensory Adaptation and Inhibits Pheromone-Sensitive Ion Channels in the Vomeronasal Organ.
J. Spehr, S. Hagendorf, J. Weiss, M. Spehr, T. Leinders-Zufall, and F. Zufall (2009)
J. Neurosci. 29, 2125-2135
   Abstract »    Full Text »    PDF »
Inhibition Shapes Sex Selectivity in the Mouse Accessory Olfactory Bulb.
R. C. Hendrickson, S. Krauthamer, J. M. Essenberg, and T. E. Holy (2008)
J. Neurosci. 28, 12523-12534
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882