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Coordination of Early Protective Immunity to Viral Infection by Regulatory T Cells
Jennifer M. Lund,
Lianne Hsing,
Thuy T. Pham,
Alexander Y. Rudensky*
Abstract:
Suppression of immune responses by regulatory T cells (Tregs)is thought to limit late stages of pathogen-specific immunityas a means of minimizing associated tissue damage. We examineda role for Tregs during mucosal herpes simplex virus infectionin mice, and observed an accelerated fatal infection with increasedviral loads in the mucosa and central nervous system after ablationof Tregs. Although augmented interferon production was detectedin the draining lymph nodes (dLNs) in Treg-deprived mice, itwas profoundly reduced at the infection site. This was associatedwith a delay in the arrival of natural killer cells, dendriticcells, and T cells to the site of infection and a sharp increasein proinflammatory chemokine levels in the dLNs. Our resultssuggest that Tregs facilitate early protective responses tolocal viral infection by allowing a timely entry of immune cellsinto infected tissue.
Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA.
* To whom correspondence should be addressed. E-mail: aruden{at}u.washington.edu
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