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From Signals to Patterns: Space, Time, and Mathematics in Developmental Biology
We now have a wealth of information about the molecular signalsthat act on cells in embryos, but how do the control systemsbased on these signals generate pattern and govern the timingof developmental events? Here, I discuss four examples to showhow mathematical modeling and quantitative experimentation cangive some useful answers. The examples concern the Bicoid gradientin the early Drosophila embryo, the dorsoventral patterningof a frog embryo by bone morphogenetic protein signals, theauxin-mediated patterning of plant meristems, and the Notch-dependentsomite segmentation clock.
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK.
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In Science Magazine
INTRODUCTION TO SPECIAL ISSUE
L. Bryan Ray (17 October 2008) Science322 (5900), 389.
[DOI: 10.1126/science.322.5900.389] |Summary »|PDF »
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A linear-encoding model explains the variability of the target morphology in regeneration.