Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 322 (5901): 587-590

Copyright © 2008 by the American Association for the Advancement of Science

H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine {gamma}-Lyase

Guangdong Yang,1,5 Lingyun Wu,2* Bo Jiang,1 Wei Yang,1 Jiansong Qi,1 Kun Cao,1 Qinghe Meng,3 Asif K. Mustafa,4 Weitong Mu,4,6 Shengming Zhang,5 Solomon H. Snyder,4* Rui Wang1,5*

Abstract: Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine. The physiological role of other gases such as carbon monoxide and hydrogen sulfide (H2S) is now receiving increasing attention. Here we show that H2S is physiologically generated by cystathionine {gamma}-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H2S levels in the serum, heart, aorta, and other tissues. Mutant mice lacking CSE display pronounced hypertension and diminished endothelium-dependent vasorelaxation. CSE is physiologically activated by calcium-calmodulin, which is a mechanism for H2S formation in response to vascular activation. These findings provide direct evidence that H2S is a physiologic vasodilator and regulator of blood pressure.

1 Department of Physiology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
2 Department of Pharmacology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
3 Department of Pathology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
4 Departments of Neuroscience, Pharmacology and Molecular Sciences and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
5 Department of Biology, Lakehead University, Thunder Bay, ON P7B 5E1, Canada.
6 Department of Medicine, Gastroenterology Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

* To whom correspondence should be addressed. E-mail: rwang{at} (R.W.), lily.wu{at} (L.W.), or ssnyder{at} (S.H.S.).

Hydrogen Sulfide Attenuates sFlt1-Induced Hypertension and Renal Damage by Upregulating Vascular Endothelial Growth Factor.
K. M. Holwerda, S. D. Burke, M. M. Faas, Z. Zsengeller, I. E. Stillman, P. M. Kang, H. van Goor, A. McCurley, I. Z. Jaffe, S. A. Karumanchi, et al. (2014)
J. Am. Soc. Nephrol. 25, 717-725
   Abstract »    Full Text »    PDF »
Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition.
M. Bucci, V. Vellecco, A. Cantalupo, V. Brancaleone, Z. Zhou, S. Evangelista, V. Calderone, A. Papapetropoulos, and G. Cirino (2014)
Cardiovasc Res 102, 138-147
   Abstract »    Full Text »    PDF »
Regulation of Cellular Communication by Signaling Microdomains in the Blood Vessel Wall.
M. Billaud, A. W. Lohman, S. R. Johnstone, L. A. Biwer, S. Mutchler, and B. E. Isakson (2014)
Pharmacol. Rev. 66, 513-569
   Abstract »    Full Text »    PDF »
Hydrogen Sulfide: A New Regulator of Osteoclastogenesis?.
M. Kurabayashi (2014)
Arterioscler Thromb Vasc Biol 34, 471-473
   Full Text »    PDF »
Cystathionine {gamma}-lyase Accelerates Osteoclast Differentiation: Identification of a Novel Regulator of Osteoclastogenesis by Proteomic Analysis.
T. Itou, N. Maldonado, I. Yamada, C. Goettsch, J. Matsumoto, M. Aikawa, S. Singh, and E. Aikawa (2014)
Arterioscler Thromb Vasc Biol 34, 626-634
   Abstract »    Full Text »    PDF »
Effect of endogenous hydrogen sulfide on the transwall gradient of the mouse colon circular smooth muscle.
L. Sha, D. R. Linden, G. Farrugia, and J. H. Szurszewski (2014)
J. Physiol. 592, 1077-1089
   Abstract »    Full Text »    PDF »
Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent.
A. L. King, D. J. Polhemus, S. Bhushan, H. Otsuka, K. Kondo, C. K. Nicholson, J. M. Bradley, K. N. Islam, J. W. Calvert, Y.-X. Tao, et al. (2014)
PNAS 111, 3182-3187
   Abstract »    Full Text »    PDF »
H2S Increases Survival during Sepsis: Protective Effect of CHOP Inhibition.
M. Ferlito, Q. Wang, W. B. Fulton, P. M. Colombani, L. Marchionni, K. Fox-Talbot, N. Paolocci, and C. Steenbergen (2014)
J. Immunol. 192, 1806-1814
   Abstract »    Full Text »    PDF »
Emergence of Hydrogen Sulfide as an Endogenous Gaseous Signaling Molecule in Cardiovascular Disease.
D. J. Polhemus and D. J. Lefer (2014)
Circ. Res. 114, 730-737
   Abstract »    Full Text »    PDF »
Urinary Sulfur Metabolites Associate with a Favorable Cardiovascular Risk Profile and Survival Benefit in Renal Transplant Recipients.
E. van den Berg, A. Pasch, W. H. Westendorp, G. Navis, E. J. Brink, R. O. B. Gans, H. van Goor, and S. J. L. Bakker (2014)
J. Am. Soc. Nephrol.
   Abstract »
Inherent variations in CO-H2S-mediated carotid body O2 sensing mediate hypertension and pulmonary edema.
Y.-J. Peng, V. V. Makarenko, J. Nanduri, C. Vasavda, G. Raghuraman, G. Yuan, M. M. Gadalla, G. K. Kumar, S. H. Snyder, and N. R. Prabhakar (2014)
PNAS 111, 1174-1179
   Abstract »    Full Text »    PDF »
Hydrogen sulphide inhibits Ca2+ release through InsP3 receptors and relaxes airway smooth muscle.
I. Castro-Piedras and J. F. Perez-Zoghbi (2013)
J. Physiol. 591, 5999-6015
   Abstract »    Full Text »    PDF »
Upregulation of heme oxygenase-1 potentiates EDH-type relaxations in the mesenteric artery of the spontaneously hypertensive rat.
Z. Li, Y. Wang, R. Y. K. Man, and P. M. Vanhoutte (2013)
Am J Physiol Heart Circ Physiol 305, H1471-H1483
   Abstract »    Full Text »    PDF »
Hydrogen sulfide-based therapeutics and gastrointestinal diseases: translating physiology to treatments.
M. V. Chan and J. L. Wallace (2013)
Am J Physiol Gastrointest Liver Physiol 305, G467-G473
   Abstract »    Full Text »    PDF »
Gasotransmitters: A Solution for the Therapeutic Dilemma in Preeclampsia?.
K. M. Holwerda, M. M. Faas, H. van Goor, and A. T. Lely (2013)
Hypertension 62, 653-659
   Full Text »    PDF »
Hydrogen Sulfide Attenuates Cardiac Dysfunction After Heart Failure Via Induction of Angiogenesis.
D. J. Polhemus, K. Kondo, S. Bhushan, S. C. Bir, C. G. Kevil, T. Murohara, D. J. Lefer, and J. W. Calvert (2013)
Circ Heart Fail 6, 1077-1086
   Abstract »    Full Text »    PDF »
Akt/eNOS signaling and PLN S-sulfhydration are involved in H2S-dependent cardiac effects in frog and rat.
R. Mazza, T. Pasqua, M. C. Cerra, T. Angelone, and A. Gattuso (2013)
Am J Physiol Regulatory Integrative Comp Physiol 305, R443-R451
   Abstract »    Full Text »    PDF »
Hydrogen Sulfide Selectively Potentiates Central Preganglionic Fast Nicotinic Synaptic Input in Mouse Superior Mesenteric Ganglion.
L. Sha, D. R. Linden, G. Farrugia, and J. H. Szurszewski (2013)
J. Neurosci. 33, 12638-12646
   Abstract »    Full Text »    PDF »
Oxygen-sensitive mitochondrial accumulation of cystathionine {beta}-synthase mediated by Lon protease.
H. Teng, B. Wu, K. Zhao, G. Yang, L. Wu, and R. Wang (2013)
PNAS 110, 12679-12684
   Abstract »    Full Text »    PDF »
Tumor-derived hydrogen sulfide, produced by cystathionine-{beta}-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer.
C. Szabo, C. Coletta, C. Chao, K. Modis, B. Szczesny, A. Papapetropoulos, and M. R. Hellmich (2013)
PNAS 110, 12474-12479
   Abstract »    Full Text »    PDF »
Structure and Kinetic Analysis of H2S Production by Human Mercaptopyruvate Sulfurtransferase.
P. K. Yadav, K. Yamada, T. Chiku, M. Koutmos, and R. Banerjee (2013)
J. Biol. Chem. 288, 20002-20013
   Abstract »    Full Text »    PDF »
Molecular Biology of Atherosclerosis.
P. N. Hopkins (2013)
Physiol Rev 93, 1317-1542
   Abstract »    Full Text »    PDF »
Dysregulation of Hydrogen Sulfide Producing Enzyme Cystathionine {gamma}-lyase Contributes to Maternal Hypertension and Placental Abnormalities in Preeclampsia.
K. Wang, S. Ahmad, M. Cai, J. Rennie, T. Fujisawa, F. Crispi, J. Baily, M. R. Miller, M. Cudmore, P. W. F. Hadoke, et al. (2013)
Circulation 127, 2514-2522
   Abstract »    Full Text »    PDF »
Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis.
S. Mani, H. Li, A. Untereiner, L. Wu, G. Yang, R. C. Austin, J. G. Dickhout, S. Lhotak, Q. H. Meng, and R. Wang (2013)
Circulation 127, 2523-2534
   Abstract »    Full Text »    PDF »
Hydrogen sulfide modulates sinusoidal constriction and contributes to hepatic micorcirculatory dysfunction during endotoxemia.
E. J. Norris, N. Feilen, N. H. Nguyen, C. R. Culberson, M. C. Shin, M. Fish, and M. G. Clemens (2013)
Am J Physiol Gastrointest Liver Physiol 304, G1070-G1078
   Abstract »    Full Text »    PDF »
Hydrogen sulfide, another simple gas with complex biology.
C. Guettler and P. Kubes (2013)
Am J Physiol Gastrointest Liver Physiol 304, G1066-G1069
   Full Text »    PDF »
Hydrogen sulfide deficiency and diabetic renal remodeling: role of matrix metalloproteinase-9.
S. Kundu, S. B. Pushpakumar, A. Tyagi, D. Coley, and U. Sen (2013)
Am J Physiol Endocrinol Metab 304, E1365-E1378
   Abstract »    Full Text »    PDF »
Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca2+-activated K+ channels and smooth muscle Ca2+ sparks.
O. Jackson-Weaver, J. M. Osmond, M. A. Riddle, J. S. Naik, L. V. G. Bosc, B. R. Walker, and N. L. Kanagy (2013)
Am J Physiol Heart Circ Physiol 304, H1446-H1454
   Abstract »    Full Text »    PDF »
Inhibition of hydrogen sulfide restores normal breathing stability and improves autonomic control during experimental heart failure.
R. Del Rio, N. J. Marcus, and H. D. Schultz (2013)
J Appl Physiol 114, 1141-1150
   Abstract »    Full Text »    PDF »
Cystathionine {gamma}-Lyase Protects against Renal Ischemia/Reperfusion by Modulating Oxidative Stress.
E. M. Bos, R. Wang, P. M. Snijder, M. Boersema, J. Damman, M. Fu, J. Moser, J.-L. Hillebrands, R. J. Ploeg, G. Yang, et al. (2013)
J. Am. Soc. Nephrol. 24, 759-770
   Abstract »    Full Text »    PDF »
Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production.
V. S. Lin, A. R. Lippert, and C. J. Chang (2013)
PNAS 110, 7131-7135
   Abstract »    Full Text »    PDF »
Hydrogen sulfide in the mouse ductus arteriosus: a naturally occurring relaxant with potential EDHF function.
B. Baragatti, E. Ciofini, D. Sodini, S. Luin, F. Scebba, and F. Coceani (2013)
Am J Physiol Heart Circ Physiol 304, H927-H934
   Abstract »    Full Text »    PDF »
Hydrogen Sulfide, the Next Potent Preventive and Therapeutic Agent in Aging and Age-Associated Diseases.
Y. Zhang, Z.-H. Tang, Z. Ren, S.-L. Qu, M.-H. Liu, L.-S. Liu, and Z.-S. Jiang (2013)
Mol. Cell. Biol. 33, 1104-1113
   Abstract »    Full Text »    PDF »
H2S Protects Against Pressure Overload-Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase.
K. Kondo, S. Bhushan, A. L. King, S. D. Prabhu, T. Hamid, S. Koenig, T. Murohara, B. L. Predmore, G. Gojon Sr, G. Gojon Jr, et al. (2013)
Circulation 127, 1116-1127
   Abstract »    Full Text »    PDF »
17{beta}-estradiol induces vasorelaxation by stimulating endothelial hydrogen sulfide release.
K. Zhou, Q. Gao, S. Zheng, S. Pan, P. Li, K. Suo, T. Simoncini, T. Wang, and X. Fu (2013)
Mol. Hum. Reprod. 19, 169-176
   Abstract »    Full Text »    PDF »
Cysteine Oxidative Posttranslational Modifications: Emerging Regulation in the Cardiovascular System.
H. S. Chung, S.-B. Wang, V. Venkatraman, C. I. Murray, and J. E. Van Eyk (2013)
Circ. Res. 112, 382-392
   Abstract »    Full Text »    PDF »
Altered Sulfide (H2S) Metabolism in Ethylmalonic Encephalopathy.
V. Tiranti and M. Zeviani (2013)
Cold Spring Harb Perspect Biol 5, a011437
   Abstract »    Full Text »    PDF »
Hydrogen Sulfide-Releasing Aspirin Derivative ACS14 Exerts Strong Antithrombotic Effects In Vitro and In Vivo.
J. Pircher, F. Fochler, T. Czermak, H. Mannell, B. F. Kraemer, M. Wornle, A. Sparatore, P. Del Soldato, U. Pohl, and F. Krotz (2012)
Arterioscler Thromb Vasc Biol 32, 2884-2891
   Abstract »    Full Text »    PDF »
Chasing Cysteine Oxidative Modifications: Proteomic Tools for Characterizing Cysteine Redox Status.
C. I. Murray and J. E. Van Eyk (2012)
Circ Cardiovasc Genet 5, 591
   Full Text »    PDF »
S-adenosylmethionine in Liver Health, Injury, and Cancer.
S. C. Lu and J. M. Mato (2012)
Physiol Rev 92, 1515-1542
   Abstract »    Full Text »    PDF »
Hydrogen sulfide mediates hypoxic vasoconstriction through a production of mitochondrial ROS in trout gills.
N. Skovgaard and K. R. Olson (2012)
Am J Physiol Regulatory Integrative Comp Physiol 303, R487-R494
   Abstract »    Full Text »    PDF »
The human carotid body transcriptome with focus on oxygen sensing and inflammation - a comparative analysis.
S. Mkrtchian, J. Kahlin, A. Ebberyd, C. Gonzalez, D. Sanchez, A. Balbir, E. W. Kostuk, M. Shirahata, M. J. Fagerlund, and L. I. Eriksson (2012)
J. Physiol. 590, 3807-3819
   Abstract »    Full Text »    PDF »
Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation.
C. Coletta, A. Papapetropoulos, K. Erdelyi, G. Olah, K. Modis, P. Panopoulos, A. Asimakopoulou, D. Gero, I. Sharina, E. Martin, et al. (2012)
PNAS 109, 9161-9166
   Abstract »    Full Text »    PDF »
Shared signaling pathways among gasotransmitters.
R. Wang (2012)
PNAS 109, 8801-8802
   Full Text »    PDF »
Hepatic peroxisome proliferator-activated receptor-{gamma}-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals.
K. Uno, T. Yamada, Y. Ishigaki, J. Imai, Y. Hasegawa, J. Gao, K. Kaneko, K. Matsusue, T. Yamazaki, Y. Oka, et al. (2012)
Eur. Heart J. 33, 1279-1289
   Abstract »    Full Text »    PDF »
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed.
R. Wang (2012)
Physiol Rev 92, 791-896
   Abstract »    Full Text »    PDF »
Transplant tolerance is associated with reduced expression of cystathionine-{gamma}-lyase that controls IL-12 production by dendritic cells and TH-1 immune responses.
R. Vuillefroy de Silly, F. Coulon, N. Poirier, V. Jovanovic, S. Brouard, V. Ferchaud-Roucher, G. Blancho, and B. Vanhove (2012)
Blood 119, 2633-2643
   Abstract »    Full Text »    PDF »
From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate.
T. Finkel (2012)
Science Signaling 5, pe10
   Abstract »    Full Text »    PDF »
Integrated Stress Response Modulates Cellular Redox State via Induction of Cystathionine {gamma}-Lyase: CROSS-TALK BETWEEN INTEGRATED STRESS RESPONSE AND THIOL METABOLISM.
J. G. Dickhout, R. E. Carlisle, D. E. Jerome, Z. Mohammed-Ali, H. Jiang, G. Yang, S. Mani, S. K. Garg, R. Banerjee, R. J. Kaufman, et al. (2012)
J. Biol. Chem. 287, 7603-7614
   Abstract »    Full Text »    PDF »
Hydrogen Sulfide Inhibits High Glucose-induced Matrix Protein Synthesis by Activating AMP-activated Protein Kinase in Renal Epithelial Cells.
H. J. Lee, M. M. Mariappan, D. Feliers, R. C. Cavaglieri, K. Sataranatarajan, H. E. Abboud, G. G. Choudhury, and B. S. Kasinath (2012)
J. Biol. Chem. 287, 4451-4461
   Abstract »    Full Text »    PDF »
Hydrogen Sulfide Is an Endogenous Potentiator of T Cell Activation.
T. W. Miller, E. A. Wang, S. Gould, E. V. Stein, S. Kaur, L. Lim, S. Amarnath, D. H. Fowler, and D. D. Roberts (2012)
J. Biol. Chem. 287, 4211-4221
   Abstract »    Full Text »    PDF »
Low hydrogen sulphide and chronic kidney disease: a dangerous liaison.
A. F. Perna and D. Ingrosso (2012)
Nephrol. Dial. Transplant. 27, 486-493
   Abstract »    Full Text »    PDF »
Precursors and inhibitors of hydrogen sulfide synthesis affect acute hypoxic pulmonary vasoconstriction in the intact lung.
J. A. Madden, S. B. Ahlf, M. W. Dantuma, K. R. Olson, and D. L. Roerig (2012)
J Appl Physiol 112, 411-418
   Abstract »    Full Text »    PDF »
Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway.
T. Morikawa, M. Kajimura, T. Nakamura, T. Hishiki, T. Nakanishi, Y. Yukutake, Y. Nagahata, M. Ishikawa, K. Hattori, T. Takenouchi, et al. (2012)
PNAS 109, 1293-1298
   Abstract »    Full Text »    PDF »
Hydrogen Sulfide as an Endothelium-Derived Hyperpolarizing Factor in Rodent Mesenteric Arteries.
G. Edwards, M. Feletou, and A. H. Weston (2012)
Circ. Res. 110, e13-e14
   Full Text »    PDF »
Response to the Letter by Edwards et al.
A. K. Mustafa, G. Sikka, S. H. Snyder, and D. E. Berkowitz (2012)
Circ. Res. 110, e15-e16
   Full Text »    PDF »
Interdependency of Cystathione {gamma}-Lyase and Cystathione {beta}-Synthase in Hydrogen Sulfide-Induced Blood Pressure Regulation in Rats.
A. Roy, A. H. Khan, M. T. Islam, M. C. Prieto, and D. S. A. Majid (2012)
Am J Hypertens 25, 74-81
   Abstract »    Full Text »    PDF »
Hydrogen Sulfide and L-Cysteine Increase Phosphatidylinositol 3,4,5-Trisphosphate (PIP3) and Glucose Utilization by Inhibiting Phosphatase and Tensin Homolog (PTEN) Protein and Activating Phosphoinositide 3-Kinase (PI3K)/Serine/Threonine Protein Kinase (AKT)/Protein Kinase C{zeta}/{lambda} (PKC{zeta}/{lambda}) in 3T3l1 Adipocytes.
P. Manna and S. K. Jain (2011)
J. Biol. Chem. 286, 39848-39859
   Abstract »    Full Text »    PDF »
Hydrogen Sulfide Protects the Retina from Light-induced Degeneration by the Modulation of Ca2+ Influx.
Y. Mikami, N. Shibuya, Y. Kimura, N. Nagahara, M. Yamada, and H. Kimura (2011)
J. Biol. Chem. 286, 39379-39386
   Abstract »    Full Text »    PDF »
Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels.
A. K. Mustafa, G. Sikka, S. K. Gazi, J. Steppan, S. M. Jung, A. K. Bhunia, V. M. Barodka, F. K. Gazi, R. K. Barrow, R. Wang, et al. (2011)
Circ. Res. 109, 1259-1268
   Abstract »    Full Text »    PDF »
Exercise Training Alters the Balance Between Vasoactive Compounds in Skeletal Muscle of Individuals With Essential Hypertension.
A. H. Hansen, M. Nyberg, J. Bangsbo, B. Saltin, and Y. Hellsten (2011)
Hypertension 58, 943-949
   Abstract »    Full Text »    PDF »
Hydrogen sulfide: its production and functions.
H. Kimura (2011)
Exp Physiol 96, 833-835
   Abstract »    Full Text »    PDF »
Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function.
K. Suzuki, G. Olah, K. Modis, C. Coletta, G. Kulp, D. Gero, P. Szoleczky, T. Chang, Z. Zhou, L. Wu, et al. (2011)
PNAS 108, 13829-13834
   Abstract »    Full Text »    PDF »
Hydrogen sulphide enhances photosynthesis through promoting chloroplast biogenesis, photosynthetic enzyme expression, and thiol redox modification in Spinacia oleracea seedlings.
J. Chen, F.-H. Wu, W.-H. Wang, C.-J. Zheng, G.-H. Lin, X.-J. Dong, J.-X. He, Z.-M. Pei, and H.-L. Zheng (2011)
J. Exp. Bot. 62, 4481-4493
   Abstract »    Full Text »    PDF »
Specificity Protein-1 as a Critical Regulator of Human Cystathionine {gamma}-Lyase in Smooth Muscle Cells.
G. Yang, Y. Pei, H. Teng, Q. Cao, and R. Wang (2011)
J. Biol. Chem. 286, 26450-26460
   Abstract »    Full Text »    PDF »
A novel approach to inhibit intracellular vitamin B6-dependent enzymes: proof of principle with human and plasmodium ornithine decarboxylase and human histidine decarboxylase.
F. Wu, P. Christen, and H. Gehring (2011)
FASEB J 25, 2109-2122
   Abstract »    Full Text »    PDF »
Mind Molecules.
S. H. Snyder (2011)
J. Biol. Chem. 286, 21023-21032
   Abstract »    Full Text »    PDF »
Intermittent Hypoxia in Rats Increases Myogenic Tone Through Loss of Hydrogen Sulfide Activation of Large-Conductance Ca2+-Activated Potassium Channels.
O. Jackson-Weaver, D. A. Paredes, L. V. G. Bosc, B. R. Walker, and N. L. Kanagy (2011)
Circ. Res. 108, 1439-1447
   Abstract »    Full Text »    PDF »
Hydrogen Sulfide-Induced Dual Vascular Effect Involves Arachidonic Acid Cascade in Rat Mesenteric Arterial Bed.
R. d'Emmanuele di Villa Bianca, R. Sorrentino, C. Coletta, E. Mitidieri, A. Rossi, V. Vellecco, A. Pinto, G. Cirino, and R. Sorrentino (2011)
J. Pharmacol. Exp. Ther. 337, 59-64
   Abstract »    Full Text »    PDF »
Hydrogen sulfide mitigates transition from compensatory hypertrophy to heart failure.
S. Givvimani, C. Munjal, R. Gargoum, U. Sen, N. Tyagi, J. C. Vacek, and S. C. Tyagi (2011)
J Appl Physiol 110, 1093-1100
   Abstract »    Full Text »    PDF »
Production of H2S by 3-mercaptopyruvate sulphurtransferase.
K. Tanizawa (2011)
J. Biochem. 149, 357-359
   Abstract »    Full Text »    PDF »
Hydrogen sulfide and cerebral microvascular tone in newborn pigs.
C. W. Leffler, H. Parfenova, S. Basuroy, J. H. Jaggar, E. S. Umstot, and A. L. Fedinec (2011)
Am J Physiol Heart Circ Physiol 300, H440-H447
   Abstract »    Full Text »    PDF »
What's new in hypertension 2010?.
J. F. E. Mann (2011)
Nephrol. Dial. Transplant. 26, 50-55
   Full Text »    PDF »
Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery.
X.-M. Xu, A. A. Turanov, B. A. Carlson, M.-H. Yoo, R. A. Everley, R. Nandakumar, I. Sorokina, S. P. Gygi, V. N. Gladyshev, and D. L. Hatfield (2010)
PNAS 107, 21430-21434
   Abstract »    Full Text »    PDF »
Hydrogen Sulfide Is an Endogenous Inhibitor of Phosphodiesterase Activity.
M. Bucci, A. Papapetropoulos, V. Vellecco, Z. Zhou, A. Pyriochou, C. Roussos, F. Roviezzo, V. Brancaleone, and G. Cirino (2010)
Arterioscler Thromb Vasc Biol 30, 1998-2004
   Abstract »    Full Text »    PDF »
Reply to Olson and Perry: H2S physiologically mediates O2 sensing.
S. H. Snyder, M. M. Gadalla, and N. R. Prabhakar (2010)
PNAS 107, E142
   Full Text »    PDF »
Cystathionine {gamma}-Lyase-deficient Mice Require Dietary Cysteine to Protect against Acute Lethal Myopathy and Oxidative Injury.
I. Ishii, N. Akahoshi, H. Yamada, S. Nakano, T. Izumi, and M. Suematsu (2010)
J. Biol. Chem. 285, 26358-26368
   Abstract »    Full Text »    PDF »
Hypoxia in the Renal Medulla: Implications for Hydrogen Sulfide Signaling.
J. Beltowski (2010)
J. Pharmacol. Exp. Ther. 334, 358-363
   Abstract »    Full Text »    PDF »
Regulation of homocysteine metabolism and methylation in human and mouse tissues.
N. C. Chen, F. Yang, L. M. Capecci, Z. Gu, A. I. Schafer, W. Durante, X.-F. Yang, and H. Wang (2010)
FASEB J 24, 2804-2817
   Abstract »    Full Text »    PDF »
Redox Biochemistry of Hydrogen Sulfide.
O. Kabil and R. Banerjee (2010)
J. Biol. Chem. 285, 21903-21907
   Abstract »    Full Text »    PDF »
H2S mediates O2 sensing in the carotid body.
Y.-J. Peng, J. Nanduri, G. Raghuraman, D. Souvannakitti, M. M. Gadalla, G. K. Kumar, S. H. Snyder, and N. R. Prabhakar (2010)
PNAS 107, 10719-10724
   Abstract »    Full Text »    PDF »
Effects of Hydrogen Sulfide-releasing L-DOPA Derivatives on Glial Activation: POTENTIAL FOR TREATING PARKINSON DISEASE.
M. Lee, V. Tazzari, D. Giustarini, R. Rossi, A. Sparatore, P. Del Soldato, E. McGeer, and P. L. McGeer (2010)
J. Biol. Chem. 285, 17318-17328
   Abstract »    Full Text »    PDF »
Hydrogen Sulfide Inhibits Plasma Renin Activity.
M. Lu, Y. H. Liu, H. S. Goh, J. J. X. Wang, Q. C. Yong, R. Wang, and J. S. Bian (2010)
J. Am. Soc. Nephrol. 21, 993-1002
   Abstract »    Full Text »    PDF »
Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells.
G. Yang, L. Wu, S. Bryan, N. Khaper, S. Mani, and R. Wang (2010)
Cardiovasc Res 86, 487-495
   Abstract »    Full Text »    PDF »
Vasoactivity of hydrogen sulfide in normoxic and anoxic turtles (Trachemys scripta).
J. A. W. Stecyk, N. Skovgaard, G. E. Nilsson, and T. Wang (2010)
Am J Physiol Regulatory Integrative Comp Physiol 298, R1225-R1239
   Abstract »    Full Text »    PDF »
Hypoxic pulmonary vasodilation: a paradigm shift with a hydrogen sulfide mechanism.
K. R. Olson, N. L. Whitfield, S. E. Bearden, J. St. Leger, E. Nilson, Y. Gao, and J. A. Madden (2010)
Am J Physiol Regulatory Integrative Comp Physiol 298, R51-R60
   Abstract »    Full Text »    PDF »
Hydrogen sulfide is an endogenous stimulator of angiogenesis.
A. Papapetropoulos, A. Pyriochou, Z. Altaany, G. Yang, A. Marazioti, Z. Zhou, M. G. Jeschke, L. K. Branski, D. N. Herndon, R. Wang, et al. (2009)
PNAS 106, 21972-21977
   Abstract »    Full Text »    PDF »
EDHF function in the ductus arteriosus: evidence against involvement of epoxyeicosatrienoic acids and 12S-hydroxyeicosatetraenoic acid.
B. Baragatti, M. L. Schwartzman, D. Angeloni, F. Scebba, E. Ciofini, D. Sodini, V. Ottaviano, S. Nencioni, A. Paolicchi, J. P. Graves, et al. (2009)
Am J Physiol Heart Circ Physiol 297, H2161-H2168
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 10 November 2009.
S. H. Snyder and A. M. VanHook (2009)
Science Signaling 2, pc20
   Abstract »    Full Text »
H2S Signals Through Protein S-Sulfhydration.
A. K. Mustafa, M. M. Gadalla, N. Sen, S. Kim, W. Mu, S. K. Gazi, R. K. Barrow, G. Yang, R. Wang, and S. H. Snyder (2009)
Science Signaling 2, ra72
   Abstract »    Full Text »    PDF »
Vascular Endothelium Expresses 3-Mercaptopyruvate Sulfurtransferase and Produces Hydrogen Sulfide.
N. Shibuya, Y. Mikami, Y. Kimura, N. Nagahara, and H. Kimura (2009)
J. Biochem. 146, 623-626
   Abstract »    Full Text »    PDF »
Neurotransmitters, Receptors, and Second Messengers Galore in 40 Years.
S. H. Snyder (2009)
J. Neurosci. 29, 12717-12721
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882