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Science 323 (5914): 649-651

Copyright © 2009 by the American Association for the Advancement of Science

PAN1: A Receptor-Like Protein That Promotes Polarization of an Asymmetric Cell Division in Maize

Heather N. Cartwright,*{dagger} John A. Humphries,* Laurie G. Smith{ddagger}

Abstract: Polarization of cell division is essential for eukaryotic development, but little is known about how this is accomplished in plants. The formation of stomatal complexes in maize involves the polarization of asymmetric subsidiary mother cell (SMC) divisions toward the adjacent guard mother cell (GMC), apparently under the influence of a GMC-derived signal. We found that the maize pan1 gene promotes the premitotic polarization of SMCs and encodes a leucine-rich repeat receptor-like protein that becomes localized in SMCs at sites of GMC contact. PAN1 has an inactive kinase domain but is required for the accumulation of a membrane-associated phosphoprotein, suggesting a function for PAN1 in signal transduction. Our findings implicate PAN1 in the transmission of an extrinsic signal that polarizes asymmetric SMC divisions toward GMCs.

Section of Cell and Developmental Biology, University of California San Diego, 9500 Gilman Drive, San Diego, CA 92093–0116, USA.

* These authors contributed equally to this work.

{dagger} Present address: Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA.

{ddagger} To whom correspondence should be addressed. E-mail: lgsmith{at}ucsd.edu

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Polarization of Subsidiary Cell Division in Maize Stomatal Complexes.
K. L. Farquharson (2012)
PLANT CELL 24, 4313
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Identification of PAN2 by Quantitative Proteomics as a Leucine-Rich Repeat-Receptor-Like Kinase Acting Upstream of PAN1 to Polarize Cell Division in Maize.
X. Zhang, M. Facette, J. A. Humphries, Z. Shen, Y. Park, D. Sutimantanapi, A. W. Sylvester, S. P. Briggs, and L. G. Smith (2012)
PLANT CELL 24, 4577-4589
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A New Role for ROP GTPases in the Polarization of Cell Division.
N. R. Hofmann (2011)
PLANT CELL 23, 2007
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ROP GTPases Act with the Receptor-Like Protein PAN1 to Polarize Asymmetric Cell Division in Maize.
J. A. Humphries, Z. Vejlupkova, A. Luo, R. B. Meeley, A. W. Sylvester, J. E. Fowler, and L. G. Smith (2011)
PLANT CELL 23, 2273-2284
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Universal rule for the symmetric division of plant cells.
S. Besson and J. Dumais (2011)
PNAS 108, 6294-6299
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The PXY-CLE41 receptor ligand pair defines a multifunctional pathway that controls the rate and orientation of vascular cell division.
J. P. Etchells and S. R. Turner (2010)
Development 137, 767-774
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Out of the Mouths of Plants: The Molecular Basis of the Evolution and Diversity of Stomatal Development.
K. M. Peterson, A. L. Rychel, and K. U. Torii (2010)
PLANT CELL 22, 296-306
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PLANT SCIENCE: Pores in Place.
F. D. Sack and J.-G. Chen (2009)
Science 323, 592-593
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