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Science 323 (5917): 1057-1060

Copyright © 2009 by the American Association for the Advancement of Science

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

Tara L. Roberts,1,2* Adi Idris,1* Jasmyn A. Dunn,1 Greg M. Kelly,1 Carol M. Burnton,1 Samantha Hodgson,1 Lani L. Hardy,1 Valerie Garceau,1{dagger} Matthew J. Sweet,1,3 Ian L. Ross,1 David A. Hume,1{dagger} Katryn J. Stacey1,3{ddagger}

Abstract: The mammalian innate immune system is activated by foreign nucleic acids. Detection of double-stranded DNA (dsDNA) in the cytoplasm triggers characteristic antiviral responses and macrophage cell death. Cytoplasmic dsDNA rapidly activated caspase 3 and caspase 1 in bone marrow–derived macrophages. We identified the HIN-200 family member and candidate lupus susceptibility factor, p202, as a dsDNA binding protein that bound stably and rapidly to transfected DNA. Knockdown studies showed p202 to be an inhibitor of DNA-induced caspase activation. Conversely, the related pyrin domain–containing HIN-200 factor, AIM2 (p210), was required for caspase activation by cytoplasmic dsDNA. This work indicates that HIN-200 proteins can act as pattern recognition receptors mediating responses to cytoplasmic dsDNA.

1 The University of Queensland, Institute for Molecular Bioscience, QLD 4072, Australia.
2 Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia.
3 The University of Queensland, School of Chemistry and Biomolecular Science, QLD 4072, Australia.

* These authors contributed equally to this work.

{dagger} Present address: The Roslin Institute, University of Edinburgh, Roslin EH259PS, Scotland, UK.

{ddagger} To whom correspondence should be addressed. E-mail: k.stacey{at}imb.uq.edu.au


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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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R. Panchanathan, X. Duan, H. Shen, V. A. K. Rathinam, L. D. Erickson, K. A. Fitzgerald, and D. Choubey (2010)
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   Abstract »    Full Text »    PDF »
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M. T.-H. Huang, B. L. Mortensen, D. J. Taxman, R. R. Craven, S. Taft-Benz, T. M. Kijek, J. R. Fuller, B. K. Davis, I. C. Allen, W. J. Brickey, et al. (2010)
J. Immunol. 185, 5476-5485
   Abstract »    Full Text »    PDF »
Inhibition of the RNA polymerase III-mediated dsDNA-sensing pathway of innate immunity by vaccinia virus protein E3.
R. Valentine and G. L. Smith (2010)
J. Gen. Virol. 91, 2221-2229
   Abstract »    Full Text »    PDF »
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   Abstract »    Full Text »    PDF »
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J. Virol. 84, 7803-7814
   Abstract »    Full Text »    PDF »
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S. E. Warren, A. Armstrong, M. K. Hamilton, D. P. Mao, I. A. Leaf, E. A. Miao, and A. Aderem (2010)
J. Immunol. 185, 818-821
   Abstract »    Full Text »    PDF »
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K. Tsuchiya, H. Hara, I. Kawamura, T. Nomura, T. Yamamoto, S. Daim, S. R. Dewamitta, Y. Shen, R. Fang, and M. Mitsuyama (2010)
J. Immunol. 185, 1186-1195
   Abstract »    Full Text »    PDF »
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P. Kankkunen, L. Teirila, J. Rintahaka, H. Alenius, H. Wolff, and S. Matikainen (2010)
J. Immunol. 184, 6335-6342
   Abstract »    Full Text »    PDF »
Inflammatory Stimuli Regulate Caspase Substrate Profiles.
N. J. Agard, D. Maltby, and J. A. Wells (2010)
Mol. Cell. Proteomics 9, 880-893
   Abstract »    Full Text »    PDF »
Comment on "Development of Murine Lupus Involves the Combined Genetic Contribution of the SLAM and Fc{gamma}R Intervals within the Nba2 Autoimmune Susceptibility Locus".
D. Choubey, R. Panchanathan, H. Shen, and X. Duan (2010)
J. Immunol. 184, 4051-4052
   Full Text »    PDF »
A visual framework for sequence analysis using n-grams and spectral rearrangement.
S. R. Maetschke, K. S. Kassahn, J. A. Dunn, S.-P. Han, E. Z. Curley, K. J. Stacey, and M. A. Ragan (2010)
Bioinformatics 26, 737-744
   Abstract »    Full Text »    PDF »
Absence of SHIP-1 Results in Constitutive Phosphorylation of Tank-Binding Kinase 1 and Enhanced TLR3-Dependent IFN-{beta} Production.
J. N. Gabhann, R. Higgs, K. Brennan, W. Thomas, J. E. Damen, N. Ben Larbi, G. Krystal, and C. A. Jefferies (2010)
J. Immunol. 184, 2314-2320
   Abstract »    Full Text »    PDF »
TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus.
K. M. Nickerson, S. R. Christensen, J. Shupe, M. Kashgarian, D. Kim, K. Elkon, and M. J. Shlomchik (2010)
J. Immunol. 184, 1840-1848
   Abstract »    Full Text »    PDF »
Extrachromosomal Histone H2B Mediates Innate Antiviral Immune Responses Induced by Intracellular Double-Stranded DNA.
K. Kobiyama, F. Takeshita, N. Jounai, A. Sakaue-Sawano, A. Miyawaki, K. J. Ishii, T. Kawai, S. Sasaki, H. Hirano, N. Ishii, et al. (2010)
J. Virol. 84, 822-832
   Abstract »    Full Text »    PDF »
Listeria monocytogenes-Infected Human Peripheral Blood Mononuclear Cells Produce IL-1{beta}, Depending on Listeriolysin O and NLRP3.
K. Meixenberger, F. Pache, J. Eitel, B. Schmeck, S. Hippenstiel, H. Slevogt, P. N'Guessan, M. Witzenrath, M. G. Netea, T. Chakraborty, et al. (2010)
J. Immunol. 184, 922-930
   Abstract »    Full Text »    PDF »
Female and Male Sex Hormones Differentially Regulate Expression of Ifi202, an Interferon-Inducible Lupus Susceptibility Gene within the Nba2 Interval.
R. Panchanathan, H. Shen, M. G. Bupp, K. A. Gould, and D. Choubey (2009)
J. Immunol. 183, 7031-7038
   Abstract »    Full Text »    PDF »
Interferons Direct an Effective Innate Response to Legionella pneumophila Infection.
C. R. Plumlee, C. Lee, A. A. Beg, T. Decker, H. A. Shuman, and C. Schindler (2009)
J. Biol. Chem. 284, 30058-30066
   Abstract »    Full Text »    PDF »
Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity.
Y. J. Crow and J. Rehwinkel (2009)
Hum. Mol. Genet. 18, R130-R136
   Abstract »    Full Text »    PDF »
Expression profile of HIN200 in leukocytes and renal biopsy of SLE patients by real-time RT-PCR.
I Kimkong, Y Avihingsanon, and N Hirankarn (2009)
Lupus 18, 1066-1072
   Abstract »    PDF »
Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation.
R. Kenworthy, D. Lambert, F. Yang, N. Wang, Z. Chen, H. Zhu, F. Zhu, C. Liu, K. Li, and H. Tang (2009)
Nucleic Acids Res. 37, 6587-6599
   Abstract »    Full Text »    PDF »
Requirement for DNA CpG Content in TLR9-Dependent Dendritic Cell Activation Induced by DNA-Containing Immune Complexes.
K. Yasuda, C. Richez, M. B. Uccellini, R. J. Richards, R. G. Bonegio, S. Akira, M. Monestier, R. B. Corley, G. A. Viglianti, A. Marshak-Rothstein, et al. (2009)
J. Immunol. 183, 3109-3117
   Abstract »    Full Text »    PDF »
Vicious circle: systemic autoreactivity in Ro52/TRIM21-deficient mice.
S. Bolland and A. Garcia-Sastre (2009)
J. Exp. Med. 206, 1647-1651
   Abstract »    Full Text »    PDF »
DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-{kappa}B.
M. Rebsamen, L. X. Heinz, E. Meylan, M.-C. Michallet, K. Schroder, K. Hofmann, J. Vazquez, C. A. Benedict, and J. Tschopp (2009)
EMBO Rep. 10, 916-922
   Abstract »    Full Text »    PDF »
Caspase-8 for Outer Harmony.
G. Sollberger and H.-D. Beer (2009)
Science Signaling 2, pe40
   Abstract »    Full Text »    PDF »
AIMing 2 Detect Foreign DNA.
A. M. Krieg (2009)
Science Signaling 2, pe39
   Abstract »    Full Text »    PDF »
Pyrin Critical to Macrophage IL-1{beta} Response to Francisella Challenge.
M. A. Gavrilin, S. Mitra, S. Seshadri, J. Nateri, F. Berhe, M. W. Hall, and M. D. Wewers (2009)
J. Immunol. 182, 7982-7989
   Abstract »    Full Text »    PDF »

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