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Science 324 (5923): 89-91

Copyright © 2009 by the American Association for the Advancement of Science

Priming in Systemic Plant Immunity

Ho Won Jung,1 Timothy J. Tschaplinski,2 Lin Wang,3* Jane Glazebrook,3 Jean T. Greenberg1{dagger}

Abstract: Plants possess inducible systemic defense responses when locally infected by pathogens. Bacterial infection results in the increased accumulation of the mobile metabolite azelaic acid, a nine-carbon dicarboxylic acid, in the vascular sap of Arabidopsis that confers local and systemic resistance against the pathogen Pseudomonas syringae. Azelaic acid primes plants to accumulate salicylic acid (SA), a known defense signal, upon infection. Mutation of the AZELAIC ACID INDUCED 1 (AZI1) gene, which is induced by azelaic acid, results in the specific loss of systemic immunity triggered by pathogen or azelaic acid and of the priming of SA induction in plants. Furthermore, the predicted secreted protein AZI1 is also important for generating vascular sap that confers disease resistance. Thus, azelaic acid and AZI1 are components of plant systemic immunity involved in priming defenses.

1 Department of Molecular Genetics and Cell Biology, The University of Chicago, 1103 East 57th Street EBC410, Chicago, IL 60637, USA.
2 Oak Ridge National Laboratory, Environmental Sciences Division, Oak Ridge, TN 37831–6341, USA.
3 Department of Plant Biology, Microbial and Plant Genomics Institute, University of Minnesota, 1500 Gortner Avenue, St. Paul, MN 55108, USA.

* Present address: Boyce Thompson Institute for Plant Research, Tower Road, Ithaca, NY 14853–1801, USA.

{dagger} To whom correspondence should be addressed. E-mail: jgreenbe{at}midway.uchicago.edu

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