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Science 324 (5930): 1064-1068

Copyright © 2009 by the American Association for the Advancement of Science

Regulators of PP2C Phosphatase Activity Function as Abscisic Acid Sensors

Yue Ma,* Izabela Szostkiewicz,* Arthur Korte,* Danièle Moes,{dagger} Yi Yang,{ddagger} Alexander Christmann, Erwin Grill§

Abstract: The plant hormone abscisic acid (ABA) acts as a developmental signal and as an integrator of environmental cues such as drought and cold. Key players in ABA signal transduction include the type 2C protein phosphatases (PP2Cs) ABI1 and ABI2, which act by negatively regulating ABA responses. In this study, we identify interactors of ABI1 and ABI2 which we have named regulatory components of ABA receptor (RCARs). In Arabidopsis, RCARs belong to a family with 14 members that share structural similarity with class 10 pathogen-related proteins. RCAR1 was shown to bind ABA, to mediate ABA-dependent inactivation of ABI1 or ABI2 in vitro, and to antagonize PP2C action in planta. Other RCARs also mediated ABA-dependent regulation of ABI1 and ABI2, consistent with a combinatorial assembly of receptor complexes.

Lehrstuhl für Botanik, Technische Universität München, Am Hochanger 4, D-85354 Freising, Germany.

* These authors contributed equally to this work.

{dagger} Present address: Plant Molecular Biology Laboratory, Public Research Centre for Health, 84, Val Fleuri, L-1526 Luxembourg, Luxembourg.

{ddagger} Present address: College of Life Sciences, Sichuan University, Chengdu, Sichuan 610064, P. R. China.

§ To whom correspondence should be addressed. E-mail: erwin.grill{at}wzw.tum.de


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Jasmonate-Dependent and COI1-Independent Defense Responses Against Sclerotinia sclerotiorum in Arabidopsis thaliana: Auxin is Part of COI1-Independent Defense Signaling.
H. U. Stotz, Y. Jikumaru, Y. Shimada, E. Sasaki, N. Stingl, M. J. Mueller, and Y. Kamiya (2011)
Plant Cell Physiol. 52, 1941-1956
   Abstract »    Full Text »    PDF »
A thermodynamic switch modulates abscisic acid receptor sensitivity.
F. Dupeux, J. Santiago, K. Betz, J. Twycross, S.-Y. Park, L. Rodriguez, M. Gonzalez-Guzman, M. R. Jensen, N. Krasnogor, M. Blackledge, et al. (2011)
EMBO J. 30, 4171-4184
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Global gene expression analysis of transgenic, mannitol-producing, and salt-tolerant Arabidopsis thaliana indicates widespread changes in abiotic and biotic stress-related genes.
Z. Chan, R. Grumet, and W. Loescher (2011)
J. Exp. Bot. 62, 4787-4803
   Abstract »    Full Text »    PDF »
FaPYR1 is involved in strawberry fruit ripening.
Y.-m. Chai, H.-f. Jia, C.-l. Li, Q.-h. Dong, and Y.-y. Shen (2011)
J. Exp. Bot. 62, 5079-5089
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A special pair of phytohormones controls excitability, slow closure, and external stomach formation in the Venus flytrap.
M. Escalante-Perez, E. Krol, A. Stange, D. Geiger, K. A. S. Al-Rasheid, B. Hause, E. Neher, and R. Hedrich (2011)
PNAS 108, 15492-15497
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Achievements and Challenges in Understanding Plant Abiotic Stress Responses and Tolerance.
F. Qin, K. Shinozaki, and K. Yamaguchi-Shinozaki (2011)
Plant Cell Physiol. 52, 1569-1582
   Abstract »    Full Text »    PDF »

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