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Science 325 (5947): 1531-1534

Copyright © 2009 by the American Association for the Advancement of Science

Cellular Basis of Itch Sensation

Yan-Gang Sun,1,* Zhong-Qiu Zhao,1,* Xiu-Li Meng,1,2 Jun Yin,1 Xian-Yu Liu,1 Zhou-Feng Chen1,{dagger}

Abstract: Itch and pain are two distinct sensations. Although our previous study suggested that gastrin-releasing peptide receptor (GRPR) is an itch-specific gene in the spinal cord, a long-standing question of whether there are separate neuronal pathways for itch and pain remains unsettled. We selectively ablated lamina I neurons expressing GRPR in the spinal cord of mice. These mice showed profound scratching deficits in response to all of the itching (pruritogenic) stimuli tested, irrespective of their histamine dependence. In contrast, pain behaviors were unaffected. Our data also suggest that GRPR+ neurons are different from the spinothalamic tract neurons that have been the focus of the debate. Together, the present study suggests that GRPR+ neurons constitute a long-sought labeled line for itch sensation in the spinal cord.

1 Departments of Anesthesiology, Psychiatry, and Developmental Biology, Washington University School of Medicine Pain Center, St. Louis, MO 63110, USA.
2 Department of Anesthesiology, Peking University Third Hospital, Beijing 100191, P.R. China.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: chenz{at}

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