Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 326 (5949): 153-156

Copyright © 2009 by the American Association for the Advancement of Science

JAK-STAT Signal Inhibition Regulates Competition in the Drosophila Testis Stem Cell Niche

Melanie Issigonis, Natalia Tulina,* Margaret de Cuevas, Crista Brawley,{dagger} Laurel Sandler, Erika Matunis{ddagger}

Abstract: Adult stem cells often reside in local microenvironments, or niches. Although niches can contain multiple types of stem cells, the coordinate regulation of stem cell behavior is poorly understood. In the Drosophila testis, Janus kinase–signal transducer and activator of transcription (JAK-STAT) signaling is directly required for maintenance of the resident germline and somatic stem cells. We found that the JAK-STAT signaling target and inhibitor Suppressor of cytokine signaling 36E (SOCS36E) is required for germline stem cell maintenance. SOCS36E suppresses JAK-STAT signaling specifically in the somatic stem cells, preventing them from displacing neighboring germline stem cells in a manner that depends on the adhesion protein integrin. Thus, in niches housing multiple stem cell types, negative feedback loops can modulate signaling, preventing one stem cell population from outcompeting the other.

Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.

* Present address: Department of Neuroscience, University of Pennsylvania School of Medicine, 232 Stemmler Hall, Philadelphia, PA 19104, USA.

{dagger} Present address: Department of Biochemistry and Molecular Biology, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.

{ddagger} To whom correspondence should be addressed. E-mail: matunis{at}jhmi.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Non-Cell Autonomous Role of E(z) to Prevent Germ Cells from Turning on a Somatic Cell Marker.
S. H. Eun, Z. Shi, K. Cui, K. Zhao, and X. Chen (2014)
Science 343, 1513-1516
   Abstract »    Full Text »    PDF »
Cell competition: how to eliminate your neighbours.
M. Amoyel and E. A. Bach (2014)
Development 141, 988-1000
   Abstract »    Full Text »    PDF »
The Maf factor Traffic jam both enables and inhibits collective cell migration in Drosophila oogenesis.
F. Gunawan, M. Arandjelovic, and D. Godt (2013)
Development 140, 2808-2817
   Abstract »    Full Text »    PDF »
Histone demethylase dUTX antagonizes JAK-STAT signaling to maintain proper gene expression and architecture of the Drosophila testis niche.
L. Tarayrah, H.-M. Herz, A. Shilatifard, and X. Chen (2013)
Development 140, 1014-1023
   Abstract »    Full Text »    PDF »
Adhesion in the stem cell niche: biological roles and regulation.
S. Chen, M. Lewallen, and T. Xie (2013)
Development 140, 255-265
   Abstract »    Full Text »    PDF »
Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis.
M. Amoyel, J. Sanny, M. Burel, and E. A. Bach (2013)
Development 140, 56-65
   Abstract »    Full Text »    PDF »
Hh signalling is essential for somatic stem cell maintenance in the Drosophila testis niche.
M. Michel, A. P. Kupinski, I. Raabe, and C. Bokel (2012)
Development 139, 2663-2669
   Abstract »    Full Text »    PDF »
Self-renewal of thymocytes in the absence of competitive precursor replenishment.
T. Boehm (2012)
J. Exp. Med. 209, 1397-1400
   Abstract »    Full Text »    PDF »
The receptor tyrosine phosphatase Lar regulates adhesion between Drosophila male germline stem cells and the niche.
S. Srinivasan, A. P. Mahowald, and M. T. Fuller (2012)
Development 139, 1381-1390
   Abstract »    Full Text »    PDF »
Germline Stem Cells.
A. Spradling, M. T. Fuller, R. E. Braun, and S. Yoshida (2011)
Cold Spring Harb Perspect Biol 3, a002642
   Abstract »    Full Text »    PDF »
Live imaging of the Drosophila spermatogonial stem cell niche reveals novel mechanisms regulating germline stem cell output.
X. R. Sheng and E. Matunis (2011)
Development 138, 3367-3376
   Abstract »    Full Text »    PDF »
The stem cell niche: lessons from the Drosophila testis.
M. de Cuevas and E. L. Matunis (2011)
Development 138, 2861-2869
   Abstract »    Full Text »    PDF »
Niche contributions to oncogenesis: emerging concepts and implications for the hematopoietic system.
M. H. G. P. Raaijmakers (2011)
Haematologica 96, 1041-1048
   Abstract »    Full Text »    PDF »
Nonautonomous Apoptosis Is Triggered by Local Cell Cycle Progression during Epithelial Replacement in Drosophila.
Y.-i. Nakajima, E. Kuranaga, K. Sugimura, A. Miyawaki, and M. Miura (2011)
Mol. Cell. Biol. 31, 2499-2512
   Abstract »    Full Text »    PDF »
lines and bowl affect the specification of cyst stem cells and niche cells in the Drosophila testis.
S. DiNardo, T. Okegbe, L. Wingert, S. Freilich, and N. Terry (2011)
Development 138, 1687-1696
   Abstract »    Full Text »    PDF »
The endoderm specifies the mesodermal niche for the germline in Drosophila via Delta-Notch signaling.
T. C. Okegbe and S. DiNardo (2011)
Development 138, 1259-1267
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882