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Science 326 (5951): 399-403

Copyright © 2009 by the American Association for the Advancement of Science

Modalities, Modes, and Models in Functional Neuroimaging

Karl J. Friston

Abstract: In this, the 21st century, human-brain mapping celebrates 21 years of cognitive activation studies. This review looks at imaging neuroscience and key ideas it has pursued; some ideas portend exciting developments, and others have failed gloriously. In terms of achievements, there is much to celebrate, in the sense that it is difficult to imagine modern neuroscience without brain imaging. I will look at recent advances from the perspectives of functional segregation and integration in the brain, paying special attention to approaches that deal with the distributed and integrated nature of neuronal processing and the questions they address.

The Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London WC1N 3BG, UK. E-mail: k.friston{at}

Effective Connectivity within Human Primary Visual Cortex Predicts Interindividual Diversity in Illusory Perception.
C. Song, D. S. Schwarzkopf, A. Lutti, B. Li, R. Kanai, and G. Rees (2013)
J. Neurosci. 33, 18781-18791
   Abstract »    Full Text »    PDF »
Coevolution of Gyral Folding and Structural Connection Patterns in Primate Brains.
H. Chen, T. Zhang, L. Guo, K. Li, X. Yu, L. Li, X. Hu, J. Han, X. Hu, and T. Liu (2013)
Cereb Cortex 23, 1208-1217
   Abstract »    Full Text »    PDF »
Predicting Functional Cortical ROIs via DTI-Derived Fiber Shape Models.
T. Zhang, L. Guo, K. Li, C. Jing, Y. Yin, D. Zhu, G. Cui, L. Li, and T. Liu (2012)
Cereb Cortex 22, 854-864
   Abstract »    Full Text »    PDF »
Upstream Dysfunction of Somatomotor Functional Connectivity After Corticospinal Damage in Stroke.
A. R. Carter, K. R. Patel, S. V. Astafiev, A. Z. Snyder, J. Rengachary, M. J. Strube, A. Pope, J. S. Shimony, C. E. Lang, G. L. Shulman, et al. (2012)
Neurorehabil Neural Repair 26, 7-19
   Abstract »    Full Text »    PDF »
How reliable are the functional connectivity networks of MEG in resting states?.
S.-H. Jin, J. Seol, J. S. Kim, and C. K. Chung (2011)
J Neurophysiol 106, 2888-2895
   Abstract »    Full Text »    PDF »
Scale-Free Properties of the Functional Magnetic Resonance Imaging Signal during Rest and Task.
B. J. He (2011)
J. Neurosci. 31, 13786-13795
   Abstract »    Full Text »    PDF »
Preserved Feedforward But Impaired Top-Down Processes in the Vegetative State.
M. Boly, M. I. Garrido, O. Gosseries, M.-A. Bruno, P. Boveroux, C. Schnakers, M. Massimini, V. Litvak, S. Laureys, and K. Friston (2011)
Science 332, 858-862
   Abstract »    Full Text »    PDF »
Reviews of Note.
Journal Watch Psychiatry 2009, 2
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Reviews of Note.
Journal Watch 2009, JP200911160000002
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