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Science 326 (5951): 399-403

Copyright © 2009 by the American Association for the Advancement of Science

Modalities, Modes, and Models in Functional Neuroimaging

Karl J. Friston

Abstract: In this, the 21st century, human-brain mapping celebrates 21 years of cognitive activation studies. This review looks at imaging neuroscience and key ideas it has pursued; some ideas portend exciting developments, and others have failed gloriously. In terms of achievements, there is much to celebrate, in the sense that it is difficult to imagine modern neuroscience without brain imaging. I will look at recent advances from the perspectives of functional segregation and integration in the brain, paying special attention to approaches that deal with the distributed and integrated nature of neuronal processing and the questions they address.

The Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London WC1N 3BG, UK. E-mail: k.friston{at}fil.ion.ucl.ac.uk


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Reviews of Note.
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Journal Watch Psychiatry 2009, 2
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Journal Watch 2009, JP200911160000002
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