Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 329 (5996): 1205-1210

Copyright © 2010 by the American Association for the Advancement of Science

The Junctional Adhesion Molecule JAML Is a Costimulatory Receptor for Epithelial {gamma}{delta} T Cell Activation

Deborah A. Witherden,1 Petra Verdino,2 Stephanie E. Rieder,1,* Olivia Garijo,1 Robyn E. Mills,1,{dagger} Luc Teyton,1 Wolfgang H. Fischer,4 Ian A. Wilson,2,3 Wendy L. Havran1,{ddagger}

Abstract: {gamma}{delta} T cells present in epithelial tissues provide a crucial first line of defense against environmental insults, including infection, trauma, and malignancy, yet the molecular events surrounding their activation remain poorly defined. Here we identify an epithelial {gamma}{delta} T cell–specific costimulatory molecule, junctional adhesion molecule–like protein (JAML). Binding of JAML to its ligand Coxsackie and adenovirus receptor (CAR) provides costimulation leading to cellular proliferation and cytokine and growth factor production. Inhibition of JAML costimulation leads to diminished {gamma}{delta} T cell activation and delayed wound closure akin to that seen in the absence of {gamma}{delta} T cells. Our results identify JAML as a crucial component of epithelial {gamma}{delta} T cell biology and have broader implications for CAR and JAML in tissue homeostasis and repair.

1 Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA.
2 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
3 The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
4 Peptide Biology, The Salk Institute, La Jolla, CA 92037, USA.

* Present address: Abbott Bioresearch Center, Worcester, MA 01605, USA

{dagger} Present address: University of California, San Francisco, San Francisco, CA 94143, USA

{ddagger} To whom correspondence should be addressed. E-mail: havran{at}scripps.edu.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cross-talk between intraepithelial {gamma}{delta} T cells and epithelial cells.
D. A. Witherden and W. L. Havran (2013)
J. Leukoc. Biol. 94, 69-76
   Abstract »    Full Text »    PDF »
B7-CD28 Costimulatory Signals Control the Survival and Proliferation of Murine and Human {gamma}{delta} T Cells via IL-2 Production.
J. C. Ribot, A. deBarros, L. Mancio-Silva, A. Pamplona, and B. Silva-Santos (2012)
J. Immunol. 189, 1202-1208
   Abstract »    Full Text »    PDF »
Dynamic migration of {gamma}{delta} intraepithelial lymphocytes requires occludin.
K. L. Edelblum, L. Shen, C. R. Weber, A. M. Marchiando, B. S. Clay, Y. Wang, I. Prinz, B. Malissen, A. I. Sperling, and J. R. Turner (2012)
PNAS 109, 7097-7102
   Abstract »    Full Text »    PDF »
Involvement of an NKG2D Ligand H60c in Epidermal Dendritic T Cell-Mediated Wound Repair.
S. Yoshida, R. H. Mohamed, M. Kajikawa, J. Koizumi, M. Tanaka, K. Fugo, N. Otsuka, K. Maenaka, H. Yagita, H. Chiba, et al. (2012)
J. Immunol. 188, 3972-3979
   Abstract »    Full Text »    PDF »
Cutting Edge: Dendritic Epidermal {gamma}{delta} T Cell Ligands Are Rapidly and Locally Expressed by Keratinocytes following Cutaneous Wounding.
H. K. Komori, D. A. Witherden, R. Kelly, K. Sendaydiego, J. M. Jameson, L. Teyton, and W. L. Havran (2012)
J. Immunol. 188, 2972-2976
   Abstract »    Full Text »    PDF »
Basolateral sorting of the coxsackie and adenovirus receptor through interaction of a canonical YXX{Phi} motif with the clathrin adaptors AP-1A and AP-1B.
J. M. Carvajal-Gonzalez, D. Gravotta, R. Mattera, F. Diaz, A. Perez Bay, A. C. Roman, R. P. Schreiner, R. Thuenauer, J. S. Bonifacino, and E. Rodriguez-Boulan (2012)
PNAS 109, 3820-3825
   Abstract »    Full Text »    PDF »
CCL20, {gamma}{delta} T cells, and IL-22 in corneal epithelial healing.
Z. Li, A. R. Burns, S. Byeseda Miller, and C. W. Smith (2011)
FASEB J 25, 2659-2668
   Abstract »    Full Text »    PDF »
Role for E-Cadherin as an Inhibitory Receptor on Epidermal {gamma}{delta} T Cells.
Y. Uchida, K. Kawai, A. Ibusuki, and T. Kanekura (2011)
J. Immunol. 186, 6945-6954
   Abstract »    Full Text »    PDF »
Go Gamma Delts!.
(2010)
Journal Watch Dermatology 2010, 2
   Full Text »
CAR'ing for the Skin.
A. S. Shaw and Y. Huang (2010)
Science 329, 1154-1155
   Abstract »    Full Text »    PDF »
Go Gamma Delts!.
Mark V. Dahl, MD and Mark V. Dahl, MD (2010)
Journal Watch 2010, JD201010150000002
   Full Text »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882