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Sequencing of Culex quinquefasciatus Establishes a Platform for Mosquito Comparative Genomics
Peter Arensburger,1,*
Karine Megy,2
Robert M. Waterhouse,3,4
Jenica Abrudan,5
Paolo Amedeo,6
Beatriz Antelo,7
Lyric Bartholomay,8
Shelby Bidwell,9
Elisabet Caler,6
Francisco Camara,9
Corey L. Campbell,10
Kathryn S. Campbell,11
Claudio Casola,12
Marta T. Castro,13
Ishwar Chandramouliswaran,6
Sinéad B. Chapman,14
Scott Christley,5
Javier Costas,15
Eric Eisenstadt,6
Cedric Feschotte,16
Claire Fraser-Liggett,17
Roderic Guigo,9
Brian Haas,14
Martin Hammond,2
Bill S. Hansson,18
Janet Hemingway,19
Sharon R. Hill,20
Clint Howarth,14
Rickard Ignell,20
Ryan C. Kennedy,5
Chinnappa D. Kodira,21
Neil F. Lobo,5
Chunhong Mao,22
George Mayhew,23
Kristin Michel,24
Akio Mori,5
Nannan Liu,25
Horacio Naveira,26
Vishvanath Nene,17,27
Nam Nguyen,16
Matthew D. Pearson,14
Ellen J. Pritham,16
Daniela Puiu,28
Yumin Qi,22
Hilary Ranson,19
Jose M. C. Ribeiro,29
Hugh M. Roberston,30
David W. Severson,5
Martin Shumway,29
Mario Stanke,31
Robert L. Strausberg,6
Cheng Sun,16
Granger Sutton,6
Zhijian (Jake) Tu,22
Jose Manuel C. Tubio,7
Maria F. Unger,5
Dana L. Vanlandingham,33
Albert J. Vilella,2
Owen White,17
Jared R. White,14
Charles S. Wondji,19
Jennifer Wortman,17
Evgeny M. Zdobnov,3,4,33
Bruce Birren,14
Bruce M. Christensen,23
Frank H. Collins,5
Anthony Cornel,32
George Dimopoulos,35
Linda I. Hannick,6
Stephen Higgs,33
Gregory C. Lanzaro,34
Daniel Lawson,2
Norman H. Lee,36
Marc A. T. Muskavitch,14,37,38
Alexander S. Raikhel,1
Peter W. Atkinson1
Abstract:Culex quinquefasciatus (the southern house mosquito) is an importantmosquito vector of viruses such as West Nile virus and St. Louisencephalitis virus, as well as of nematodes that cause lymphaticfilariasis. C. quinquefasciatus is one species within the Culexpipiens species complex and can be found throughout tropicaland temperate climates of the world. The ability of C. quinquefasciatusto take blood meals from birds, livestock, and humans contributesto its ability to vector pathogens between species. Here, wedescribe the genomic sequence of C. quinquefasciatus: Its repertoireof 18,883 protein-coding genes is 22% larger than that of Aedesaegypti and 52% larger than that of Anopheles gambiae with multiplegene-family expansions, including olfactory and gustatory receptors,salivary gland genes, and genes associated with xenobiotic detoxification.
1 Center for Disease Vector Research, University of California Riverside, Riverside, CA 92521, USA. 2 European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. 3 University of Geneva Medical School, 1 rue Michel-Servet, 1211 Geneva, Switzerland. 4 Swiss Institute of Bioinformatics, 1 rue Michel-Servet, 1211 Geneva, Switzerland. 5 University of Notre Dame, Notre Dame, IN 46556, USA. 6 J. Craig Venter Institute, Rockville, MD 20850, USA. 7 Complexo Hospitalario Universitario de Santiago, Santiago de Compostela 15706, Spain. 8 Iowa State University, Ames, IA 50011, USA. 9 Center for Genomic Regulation, Universitat Pompeu Fabra, E-08003 Barcelona, Catalonia, Spain. 10 Colorado State University, Fort Collins, CO 80523, USA. 11 Harvard University, Cambridge, MA 02138, USA. 12 Indiana University, Bloomington, IN 47405–3700, USA. 13 Programa d’Epigenética i Biologia del Cáncer, Hospital Duran i Reynals, 08907 Hospitalet de Llobregat, Barcelona, Spain. 14 The Broad Institute, Cambridge, MA 02142, USA. 15 Fundación Pública Galega de Medicina Xenómica–Servizo Galego de Saúde, Santiago de Compostela 15706, Spain. 16 University of Texas Arlington, Arlington, TX 76019, USA. 17 Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA. 18 Max Planck Institute for Chemical Ecology, 07749 Jena, Germany. 19 Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK. 20 Swedish University of Agricultural Sciences, 230 53 Alnarp, Sweden. 21 454 Life Sciences, the Roche Group, Branford, CT 06405, USA. 22 Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. 23 University of Wisconsin, Madison, WI 53706, USA. 24 Kansas State University, Manhattan, KS 66506, USA. 25 Auburn University, Auburn, AL 36849, USA. 26 Departamento de Biloxía Celular e Molecular, Universidade da Coruña, 15071 A, Coruña, Spain. 27 International Livestock Research Institute, Nairobi, Kenya. 28 Center for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA. 29 National Institutes of Health, Bethesda, MD 20892, USA. 30 University of Illinois Urbana-Champaign, Urbana, IL 61801, USA. 31 University of Göttingen, 37077 Göttingen, Germany. 32 University of Texas Medical Branch, Galveston, TX 77555, USA. 33 Imperial College London, South Kensington Campus, London SW7 2AZ, UK. 34 University of California Davis, Parlier, CA 93648, USA. 35 Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA. 36 George Washington University Medical Center, Washington, DC 20037, USA. 37 Boston College, Chestnut Hill, MA 02467, USA. 38 Harvard School of Public Health, Boston, MA 02115, USA.
* To whom correspondence should be addressed. E-mail: arensburger{at}gmail.com
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