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Science 330 (6009): 1338-1339

Copyright © 2010 by the American Association for the Advancement of Science

On Getting There from Here

Steven L. McKnight

Abstract: Studies on a variety of interesting biological problems, ranging from circadian rhythm to cancer cell growth to longevity, have begun to give evidence that the physiological state of cells and tissues reflects both the cell’s regulatory systems and its state of intermediary metabolism. It is appreciated that the regulatory state of a cell or tissue, as driven by transcription factors and signaling pathways, can impose itself upon the dynamics of metabolic state. It follows that the reciprocal must also be the case, that metabolic state will feed back to impose itself on regulatory state. An appreciation and understanding of this reciprocity may be required to crack open problems in biological research that have heretofore been insoluble.

Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390–9152, USA. E-mail: steven.mcknight{at}

Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation.
A. Bordbar, M. L. Mo, E. S. Nakayasu, A. C. Schrimpe-Rutledge, Y.-M. Kim, T. O. Metz, M. B. Jones, B. C. Frank, R. D. Smith, S. N. Peterson, et al. (2014)
Mol Syst Biol 8, 558
   Abstract »    Full Text »    PDF »
Postindustrial Metabolism: Fat Knowledge.
H. Landecker (2013)
Public Culture 25, 495-522
   Abstract »    Full Text »    PDF »
Quantitative Proteomics Reveals That Enzymes of the Ketogenic Pathway Are Associated with Prostate Cancer Progression.
P. Saraon, D. Cretu, N. Musrap, G. S. Karagiannis, I. Batruch, A. P. Drabovich, T. van der Kwast, A. Mizokami, C. Morrissey, K. Jarvi, et al. (2013)
Mol. Cell. Proteomics 12, 1589-1601
   Abstract »    Full Text »    PDF »
Conquering Cancer in Our Lifetime: New Diagnostic and Therapeutic Trends.
E. P. Diamandis, R. C. Bast Jr., and C. Lopez-Otin (2013)
Clin. Chem. 59, 1-3
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A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo.
Y. Liu, Y. Cao, W. Zhang, S. Bergmeier, Y. Qian, H. Akbar, R. Colvin, J. Ding, L. Tong, S. Wu, et al. (2012)
Mol. Cancer Ther. 11, 1672-1682
   Abstract »    Full Text »    PDF »
Effects of Excess Succinate and Retrograde Control of Metabolite Accumulation in Yeast Tricarboxylic Cycle Mutants.
A.-P. Lin, S. L. Anderson, K. I. Minard, and L. McAlister-Henn (2011)
J. Biol. Chem. 286, 33737-33746
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Metabolic status rather than cell cycle signals control quiescence entry and exit.
D. Laporte, A. Lebaudy, A. Sahin, B. Pinson, J. Ceschin, B. Daignan-Fornier, and I. Sagot (2011)
J. Cell Biol. 192, 949-957
   Abstract »    Full Text »    PDF »
Regulation of Metabolism by Hypoxia-Inducible Factor 1.
G. L. Semenza (2011)
Cold Spring Harb Symp Quant Biol 76, 347-353
   Abstract »    Full Text »    PDF »

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