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Science 330 (6009): 1349-1354

Copyright © 2010 by the American Association for the Advancement of Science

Circadian Integration of Metabolism and Energetics

Joseph Bass1,2,3,4,*, and Joseph S. Takahashi5,6

Abstract: Circadian clocks align behavioral and biochemical processes with the day/night cycle. Nearly all vertebrate cells possess self-sustained clocks that couple endogenous rhythms with changes in cellular environment. Genetic disruption of clock genes in mice perturbs metabolic functions of specific tissues at distinct phases of the sleep/wake cycle. Circadian desynchrony, a characteristic of shift work and sleep disruption in humans, also leads to metabolic pathologies. Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions.

1 Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA.
2 Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208–3520, USA.
3 Weinberg College of Arts and Sciences, Northwestern University, Evanston, IL 60208–3520, USA.
4 Center for Sleep and Circadian Biology, Northwestern University, Evanston, IL 60208–3520, USA.
5 Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390–9111, USA.
6 Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390–9111, USA.

* To whom correspondence should be addressed. E-mail: j-bass{at}northwestern.edu


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