Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 331 (6019): 924-928

Copyright © 2011 by the American Association for the Advancement of Science

Early Tagging of Cortical Networks Is Required for the Formation of Enduring Associative Memory

Edith Lesburguères, Oliviero L. Gobbo, Stéphanie Alaux-Cantin, Anne Hambucken, Pierre Trifilieff, Bruno Bontempi*

Abstract: Although formation and stabilization of long-lasting associative memories are thought to require time-dependent coordinated hippocampal-cortical interactions, the underlying mechanisms remain unclear. Here, we present evidence that neurons in the rat cortex must undergo a "tagging process" upon encoding to ensure the progressive hippocampal-driven rewiring of cortical networks that support remote memory storage. This process was AMPA- and N-methyl-D-aspartate receptor–dependent, information-specific, and capable of modulating remote memory persistence by affecting the temporal dynamics of hippocampal-cortical interactions. Post-learning reinforcement of the tagging process via time-limited epigenetic modifications resulted in improved remote memory retrieval. Thus, early tagging of cortical networks is a crucial neurobiological process for remote memory formation whose functional properties fit the requirements imposed by the extended time scale of systems-level memory consolidation.

Institut des Maladies Neurodégénératives, CNRS UMR 5293, Universités Bordeaux 1 et 2, Avenue des Facultés, 33405 Talence, France.

* To whom correspondence should be addressed. E-mail: bruno.bontempi{at}

Learning-Induced Plasticity Regulates Hippocampal Sharp Wave-Ripple Drive.
G. Girardeau, A. Cei, and M. Zugaro (2014)
J. Neurosci. 34, 5176-5183
   Abstract »    Full Text »    PDF »
Extinction of Remotely Acquired Fear Depends on an Inhibitory NR2B/PKA Pathway in the Retrosplenial Cortex.
K. A. Corcoran, K. Leaderbrand, and J. Radulovic (2013)
J. Neurosci. 33, 19492-19498
   Abstract »    Full Text »    PDF »
Axonal Sprouting and Formation of Terminals in the Adult Cerebellum during Associative Motor Learning.
H.-J. Boele, S. K. E. Koekkoek, C. I. De Zeeuw, and T. J. H. Ruigrok (2013)
J. Neurosci. 33, 17897-17907
   Abstract »    Full Text »    PDF »
New methods for understanding systems consolidation.
K. K. Tayler and B. J. Wiltgen (2013)
Learn. Mem. 20, 553-557
   Abstract »    Full Text »    PDF »
A Novel Activator of CBP/p300 Acetyltransferases Promotes Neurogenesis and Extends Memory Duration in Adult Mice.
S. Chatterjee, P. Mizar, R. Cassel, R. Neidl, B. R. Selvi, D. V. Mohankrishna, B. M. Vedamurthy, A. Schneider, O. Bousiges, C. Mathis, et al. (2013)
J. Neurosci. 33, 10698-10712
   Abstract »    Full Text »    PDF »
Encoding and Retrieval of Artificial Visuoauditory Memory Traces in the Auditory Cortex Requires the Entorhinal Cortex.
X. Chen, Y. Guo, J. Feng, Z. Liao, X. Li, H. Wang, X. Li, and J. He (2013)
J. Neurosci. 33, 9963-9974
   Abstract »    Full Text »    PDF »
Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory.
C. Katche, G. Dorman, L. Slipczuk, M. Cammarota, and J. H. Medina (2013)
Learn. Mem. 20, 170-173
   Abstract »    Full Text »    PDF »
Epigenetic regulation of memory formation and maintenance.
I. B. Zovkic, M. C. Guzman-Karlsson, and J. D. Sweatt (2013)
Learn. Mem. 20, 61-74
   Abstract »    Full Text »    PDF »
Detecting Representations of Recent and Remote Autobiographical Memories in vmPFC and Hippocampus.
H. M. Bonnici, M. J. Chadwick, A. Lutti, D. Hassabis, N. Weiskopf, and E. A. Maguire (2012)
J. Neurosci. 32, 16982-16991
   Abstract »    Full Text »    PDF »
Involvement of the anterior cingulate cortex in formation, consolidation, and reconsolidation of recent and remote contextual fear memory.
E. O. Einarsson and K. Nader (2012)
Learn. Mem. 19, 449-452
   Abstract »    Full Text »    PDF »
Functional Dissociation between Anterior and Posterior Temporal Cortical Regions during Retrieval of Remote Memory.
T. Watanabe, H. M. Kimura, S. Hirose, H. Wada, Y. Imai, T. Machida, I. Shirouzu, Y. Miyashita, and S. Konishi (2012)
J. Neurosci. 32, 9659-9670
   Abstract »    Full Text »    PDF »
Gcm/Glide-dependent conversion into glia depends on neural stem cell age, but not on division, triggering a chromatin signature that is conserved in vertebrate glia.
H. Flici, B. Erkosar, O. Komonyi, O. F. Karatas, P. Laneve, and A. Giangrande (2011)
Development 138, 4167-4178
   Abstract »    Full Text »    PDF »
Schema-Dependent Gene Activation and Memory Encoding in Neocortex.
D. Tse, T. Takeuchi, M. Kakeyama, Y. Kajii, H. Okuno, C. Tohyama, H. Bito, and R. G. M. Morris (2011)
Science 333, 891-895
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882