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Science 331 (6021): 1207-1210

Copyright © 2011 by the American Association for the Advancement of Science

Enhancement of Consolidated Long-Term Memory by Overexpression of Protein Kinase M{zeta} in the Neocortex

Reut Shema,1 Sharon Haramati,1 Shiri Ron,1 Shoshi Hazvi,1 Alon Chen,1 Todd Charlton Sacktor,2 Yadin Dudai1,*

Abstract: Memories are more easily disrupted than improved. Many agents can impair memories during encoding and consolidation. In contrast, the armamentarium of potential memory enhancers is so far rather modest. Moreover, the effect of the latter appears to be limited to enhancing new memories during encoding and the initial period of cellular consolidation, which can last from a few minutes to hours after learning. Here, we report that overexpression in the rat neocortex of the protein kinase C isozyme protein kinase M{zeta} (PKM{zeta}) enhances long-term memory, whereas a dominant negative PKM{zeta} disrupts memory, even long after memory has been formed.

1 Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
2 Departments of Physiology, Pharmacology, and Neurology, The Robert F. Furchgott Center for Neural and Behavioral Science, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA.

* To whom correspondence should be addressed. E-mail: yadin.dudai{at}weizmann.ac.il

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