Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Subscribe

Logo for

Science 332 (6027): 354-358

Copyright © 2011 by the American Association for the Advancement of Science

Specificity of Drosophila Cytonemes for Distinct Signaling Pathways

Sougata Roy, Frank Hsiung,* Thomas B. Kornberg{dagger}

Abstract: Cytonemes are types of filopodia in the Drosophila wing imaginal disc that are proposed to serve as conduits in which morphogen signaling proteins move between producing and target cells. We investigated the specificity of cytonemes that are made by target cells. Cells in wing discs made cytonemes that responded specifically to Decapentaplegic (Dpp) and cells in eye discs made cytonemes that responded specifically to Spitz (the Drosophila epidermal growth factor protein). Tracheal cells had at least two types: one made in response to Branchless (a Drosophila fibroblast growth factor protein, Bnl), to which they segregate the Bnl receptor, and another to which they segregate the Dpp receptor. We conclude that cells can make several types of cytonemes, each of which responds specifically to a signaling pathway by means of the selective presence of a particular signaling protein receptor that has been localized to that cytoneme.

Cardiovascular Research Institute and Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.

* Present address: BioRad Laboratories, Hercules, CA 94547, USA.

{dagger} To whom correspondence should be addressed. E-mail: tkornberg{at}ucsf.edu

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Absolute requirement of cholesterol binding for Hedgehog gradient formation in Drosophila.
A. Ducuing, B. Mollereau, J. D. Axelrod, and S. Vincent (2013)
Biology Open
   Abstract »    Full Text »    PDF »
Morphogen transport.
P. Muller, K. W. Rogers, S. R. Yu, M. Brand, and A. F. Schier (2013)
Development 140, 1621-1638
   Abstract »    Full Text »    PDF »
RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C.
K. Koizumi, K. Takano, A. Kaneyasu, H. Watanabe-Takano, E. Tokuda, T. Abe, N. Watanabe, T. Takenawa, and T. Endo (2012)
Mol. Biol. Cell 23, 4647-4661
   Abstract »    Full Text »    PDF »
Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning.
N. Perrimon, C. Pitsouli, and B.-Z. Shilo (2012)
Cold Spring Harb Perspect Biol 4, a005975
   Abstract »    Full Text »    PDF »
Wiring through tunneling nanotubes - from electrical signals to organelle transfer.
S. Abounit and C. Zurzolo (2012)
J. Cell Sci. 125, 1089-1098
   Abstract »    Full Text »    PDF »
Direct Delivery Mechanisms of Morphogen Dispersion.
S. Roy and T. B. Kornberg (2011)
Science Signaling 4, pt8
   Abstract »    Full Text »    PDF »
Cytonemes Show Their Colors.
M. Affolter and K. Basler (2011)
Science 332, 312-313
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882