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Science 333 (6041): 405-

Copyright © 2011 by the American Association for the Advancement of Science

Comment on "Activation of β-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine"

Kenneth M. Murphy

Abstract: Manicassamy et al. (Reports, 13 August 2010, p. 849) deleted β-catenin in intestinal immune cells using a CD11c-driven Cre recombinase, which decreased anti-inflammatory mediators and increased inflammatory bowel disease. However, the deletion of β-catenin in macrophages remains a caveat to their interpretation that Wnt signaling programs dendritic cells into a tolerogenic state. Development of strains expressing Cre in a more finely lineage-restricted pattern may help resolve this issue.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

E-mail: kmurphy{at}

Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.
A. T. Satpathy, W. KC, J. C. Albring, B. T. Edelson, N. M. Kretzer, D. Bhattacharya, T. L. Murphy, and K. M. Murphy (2012)
J. Exp. Med. 209, 1135-1152
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Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage.
M. M. Meredith, K. Liu, G. Darrasse-Jeze, A. O. Kamphorst, H. A. Schreiber, P. Guermonprez, J. Idoyaga, C. Cheong, K.-H. Yao, R. E. Niec, et al. (2012)
J. Exp. Med. 209, 1153-1165
   Abstract »    Full Text »    PDF »
Regulation and function of the E-cadherin/catenin complex in cells of the monocyte-macrophage lineage and DCs.
J. Van den Bossche, B. Malissen, A. Mantovani, P. De Baetselier, and J. A. Van Ginderachter (2012)
Blood 119, 1623-1633
   Abstract »    Full Text »    PDF »
Response to Comment on "Activation of {beta}-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine".
S. Manicassamy and B. Pulendran (2011)
Science 333, 405
   Abstract »    Full Text »    PDF »

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