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Science 333 (6041): 405-

Copyright © 2011 by the American Association for the Advancement of Science

Comment on "Activation of β-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine"

Kenneth M. Murphy

Abstract: Manicassamy et al. (Reports, 13 August 2010, p. 849) deleted β-catenin in intestinal immune cells using a CD11c-driven Cre recombinase, which decreased anti-inflammatory mediators and increased inflammatory bowel disease. However, the deletion of β-catenin in macrophages remains a caveat to their interpretation that Wnt signaling programs dendritic cells into a tolerogenic state. Development of strains expressing Cre in a more finely lineage-restricted pattern may help resolve this issue.

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

E-mail: kmurphy{at}wustl.edu


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