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Science 333 (6041): 405-

Copyright © 2011 by the American Association for the Advancement of Science

Response to Comment on "Activation of β-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine"

Santhakumar Manicassamy1, and Bali Pulendran1,2,*

Abstract: Murphy argues that deletion of β-catenin in macrophages is a caveat to our interpretation that Wnt signaling programs dendritic cells (DCs) into a tolerogenic state in the gut. However, our data demonstrate that β-catenin–deficient DCs are greatly impaired in inducing regulatory T cells, and induce enhanced T helper 17 (TH17)/TH1 responses. Assessing the relative importance of DCs versus macrophages in intestinal tolerance must await tools that permit the genetic deletion of the numerous DC and macrophage subsets in the intestine.

1 Emory Vaccine Center and Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA.
2 Department of Pathology, Emory University, 1364 Clifton Road NE, Atlanta, GA 30322, USA.

* To whom correspondence should be addressed. E-mail: bpulend{at}

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