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Science 333 (6042): 601-607

Copyright © 2011 by the American Association for the Advancement of Science

Evidence for Network Evolution in an Arabidopsis Interactome Map

Arabidopsis Interactome Mapping Consortium*,{dagger}

Abstract: Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.

* All authors with their affiliations and contributions are listed at the end of the paper.

{dagger} To whom correspondence should be addressed. E-mail: marc_vidal{at}dfci.harvard.edu; ecker{at}salk.edu; pascal_braun{at}dfci.harvard.edu; david_hill{at}dfci.harvard.edu


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