Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 333 (6048): 1458-1462

Copyright © 2011 by the American Association for the Advancement of Science

Light-Induced Structural and Functional Plasticity in Drosophila Larval Visual System

Quan Yuan, Yang Xiang, Zhiqiang Yan, Chun Han, Lily Yeh Jan, Yuh Nung Jan*

Abstract: How to build and maintain a reliable yet flexible circuit is a fundamental question in neurobiology. The nervous system has the capacity for undergoing modifications to adapt to the changing environment while maintaining its stability through compensatory mechanisms, such as synaptic homeostasis. Here, we describe our findings in the Drosophila larval visual system, where the variation of sensory inputs induced substantial structural plasticity in dendritic arbors of the postsynaptic neuron and concomitant changes to its physiological output. Furthermore, our genetic analyses have identified the cyclic adenosine monophosphate (cAMP) pathway and a previously uncharacterized cell surface molecule as critical components in regulating experience-dependent modification of the postsynaptic dendrite morphology in Drosophila.

Howard Hughes Medical Institute, Department of Physiology and Biochemistry, University of California, San Francisco, 1550 4th Street, San Francisco, CA 94158, USA.

* To whom correspondence should be addressed. E-mail: yuhnung.jan{at}ucsf.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
New Approaches for Studying Synaptic Development, Function, and Plasticity Using Drosophila as a Model System.
C. A. Frank, X. Wang, C. A. Collins, A. A. Rodal, Q. Yuan, P. Verstreken, and D. K. Dickman (2013)
J. Neurosci. 33, 17560-17568
   Abstract »    Full Text »    PDF »
A Mechanism for Circadian Control of Pacemaker Neuron Excitability.
M. Ruben, M. D. Drapeau, D. Mizrak, and J. Blau (2012)
J Biol Rhythms 27, 353-364
   Abstract »    Full Text »    PDF »
Analysis of functional neuronal connectivity in the Drosophila brain.
Z. Yao, A. M. Macara, K. R. Lelito, T. Y. Minosyan, and O. T. Shafer (2012)
J Neurophysiol 108, 684-696
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882