Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 334 (6055): 528-531

Copyright © 2011 by the American Association for the Advancement of Science

Fatty Acids Identified in the Burmese Python Promote Beneficial Cardiac Growth

Cecilia A. Riquelme,1 Jason A. Magida,1 Brooke C. Harrison,1 Christopher E. Wall,1 Thomas G. Marr,2 Stephen M. Secor,3 Leslie A. Leinwand1,*

Abstract: Burmese pythons display a marked increase in heart mass after a large meal. We investigated the molecular mechanisms of this physiological heart growth with the goal of applying this knowledge to the mammalian heart. We found that heart growth in pythons is characterized by myocyte hypertrophy in the absence of cell proliferation and by activation of physiological signal transduction pathways. Despite high levels of circulating lipids, the postprandial python heart does not accumulate triglycerides or fatty acids. Instead, there is robust activation of pathways of fatty acid transport and oxidation combined with increased expression and activity of superoxide dismutase, a cardioprotective enzyme. We also identified a combination of fatty acids in python plasma that promotes physiological heart growth when injected into either pythons or mice.

1 Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
2 Hiberna Corporation, Boulder, CO 80302, USA.
3 Department of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487, USA.

* To whom correspondence should be addressed. E-mail: leslie.leinwand{at}colorado.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cardiac function of the naked mole-rat: ecophysiological responses to working underground.
K. M. Grimes, A. Voorhees, Y. A. Chiao, H.-C. Han, M. L. Lindsey, and R. Buffenstein (2014)
Am J Physiol Heart Circ Physiol 306, H730-H737
   Abstract »    Full Text »    PDF »
The Burmese python genome reveals the molecular basis for extreme adaptation in snakes.
T. A. Castoe, A. P. J. de Koning, K. T. Hall, D. C. Card, D. R. Schield, M. K. Fujita, R. P. Ruggiero, J. F. Degner, J. M. Daza, W. Gu, et al. (2013)
PNAS 110, 20645-20650
   Abstract »    Full Text »    PDF »
Cardiac Metabolism and its Interactions With Contraction, Growth, and Survival of Cardiomyocytes.
S. C. Kolwicz Jr, S. Purohit, and R. Tian (2013)
Circ. Res. 113, 603-616
   Abstract »    Full Text »    PDF »
Sulfo-N-succinimidyl Oleate (SSO) Inhibits Fatty Acid Uptake and Signaling for Intracellular Calcium via Binding CD36 Lysine 164: SSO ALSO INHIBITS OXIDIZED LOW DENSITY LIPOPROTEIN UPTAKE BY MACROPHAGES.
O. Kuda, T. A. Pietka, Z. Demianova, E. Kudova, J. Cvacka, J. Kopecky, and N. A. Abumrad (2013)
J. Biol. Chem. 288, 15547-15555
   Abstract »    Full Text »    PDF »
Model Systems for Cardiovascular Regenerative Biology.
J. C. Garbern, C. L. Mummery, and R. T. Lee (2013)
Cold Spring Harb Perspect Med 3, a014019
   Abstract »    Full Text »    PDF »
Can Exercise Teach Us How to Treat Heart Disease?.
N. Mann and A. Rosenzweig (2012)
Circulation 126, 2625-2635
   Full Text »    PDF »
Plasma Phospholipid Concentration of Cis-Palmitoleic Acid and Risk of Heart Failure.
L. Djousse, N. L. Weir, N. Q. Hanson, M. Y. Tsai, and J. M. Gaziano (2012)
Circ Heart Fail 5, 703-709
   Abstract »    Full Text »    PDF »
Animal athletes: a performance review.
N. C. C. Sharp (2012)
Vet Rec 171, 87-94
   Abstract »    Full Text »    PDF »
Humoral regulation of heart rate during digestion in pythons (Python molurus and Python regius).
S. Enok, L. S. Simonsen, S. V. Pedersen, T. Wang, and N. Skovgaard (2012)
Am J Physiol Regulatory Integrative Comp Physiol 302, R1176-R1183
   Abstract »    Full Text »    PDF »
Elucidating Nature's Solutions to Heart, Lung, and Blood Diseases and Sleep Disorders.
H. V. Carey, S. L. Martin, B. A. Horwitz, L. Yan, S. M. Bailey, J. Podrabsky, J. F. Storz, R. M. Ortiz, R. P. Wong, and D. A. Lathrop (2012)
Circ. Res. 110, 915-921
   Abstract »    Full Text »    PDF »
Regulation of maternal phospholipid composition and IP3-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans.
M. Kniazeva, H. Shen, T. Euler, C. Wang, and M. Han (2012)
Genes & Dev. 26, 554-566
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882