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Science 334 (6056): 670-674

Copyright © 2011 by the American Association for the Advancement of Science

Drosophila Microbiome Modulates Host Developmental and Metabolic Homeostasis via Insulin Signaling

Seung Chul Shin,1,3,*,{dagger} Sung-Hee Kim,1,{dagger} Hyejin You,1,2 Boram Kim,1,2 Aeri C. Kim,1,2 Kyung-Ah Lee,1 Joo-Heon Yoon,3 Ji-Hwan Ryu,3 Won-Jae Lee1,{ddagger}

Abstract: The symbiotic microbiota profoundly affect many aspects of host physiology; however, the molecular mechanisms underlying host-microbe cross-talk are largely unknown. Here, we show that the pyrroloquinoline quinone–dependent alcohol dehydrogenase (PQQ-ADH) activity of a commensal bacterium, Acetobacter pomorum, modulates insulin/insulin-like growth factor signaling (IIS) in Drosophila to regulate host homeostatic programs controlling developmental rate, body size, energy metabolism, and intestinal stem cell activity. Germ-free animals monoassociated with PQQ-ADH mutant bacteria displayed severe deregulation of developmental and metabolic homeostasis. Importantly, these defects were reversed by enhancing host IIS or by supplementing the diet with acetic acid, the metabolic product of PQQ-ADH.

1 School of Biological Science, Seoul National University and National Creative Research Initiative Center for Symbiosystem, Seoul 151-742, South Korea.
2 Department of Bioinspired Science and Division of Life and Pharmaceutical Science, Ewha Woman’s University, Seoul 120-750, South Korea.
3 Research Center for Human Natural Defense System, Yonsei University College of Medicine, CPO Box 8044 Seoul, South Korea.

* Present address: Korea Polar Research Institute, Incheon 406-840, South Korea.

{dagger} These authors contributed equally to this work.

{ddagger} To whom correspondence should be addressed. E-mail: lwj{at}snu.ac.kr

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