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Science 334 (6061): 1405-1408

Copyright © 2011 by the American Association for the Advancement of Science

Pathogen Effectors Target Arabidopsis EDS1 and Alter Its Interactions with Immune Regulators

Saikat Bhattacharjee,1 Morgan K. Halane,2,* Sang Hee Kim,1,{dagger} Walter Gassmann1,{ddagger}

Abstract: Plant resistance proteins detect the presence of specific pathogen effectors and initiate effector-triggered immunity. Few immune regulators downstream of resistance proteins have been identified, none of which are known virulence targets of effectors. We show that Arabidopsis ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1), a positive regulator of basal resistance and of effector-triggered immunity specifically mediated by Toll–interleukin-1 receptor–nucleotide binding–leucine-rich repeat (TIR-NB-LRR) resistance proteins, forms protein complexes with the TIR-NB-LRR disease resistance proteins RPS4 and RPS6 and with the negative immune regulator SRFR1 at a cytoplasmic membrane. Further, the cognate bacterial effectors AvrRps4 and HopA1 disrupt these EDS1 complexes. Tight association of EDS1 with TIR-NB-LRR–mediated immunity may therefore derive mainly from being guarded by TIR-NB-LRR proteins, and activation of this branch of effector-triggered immunity may directly connect to the basal resistance signaling pathway via EDS1.

1 Division of Plant Sciences, Christopher S. Bond Life Sciences Center and Interdisciplinary Plant Group, University of Missouri, Columbia, MO 65211, USA.
2 Department of English, University of Missouri, Columbia, MO 65211, USA.

* Present address: Lancaster University, Lancaster LA1 4YW, UK.

{dagger} Present address: Department of Biology, Indiana University, Bloomington, IN 47408, USA.

{ddagger} To whom correspondence should be addressed. E-mail: gassmannw{at}

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