Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 335 (6075): 1510-1513

Copyright © 2012 by the American Association for the Advancement of Science

Glucocorticoids Can Induce PTSD-Like Memory Impairments in Mice

Nadia Kaouane,1,2,3 Yves Porte,1,2,* Monique Vallée,2,3 Laurent Brayda-Bruno,1,2,3 Nicole Mons,1,2,{dagger} Ludovic Calandreau,4 Aline Marighetto,1,2,3 Pier Vincenzo Piazza,2,3,{ddagger},§ Aline Desmedt1,2,3,{ddagger},§

Abstract: Posttraumatic stress disorder (PTSD) is characterized by a hypermnesia of the trauma and by a memory impairment that decreases the ability to restrict fear to the appropriate context. Infusion of glucocorticoids in the hippocampus after fear conditioning induces PTSD-like memory impairments and an altered pattern of neural activation in the hippocampal-amygdalar circuit. Mice become unable to identify the context as the correct predictor of the threat and show fear responses to a discrete cue not predicting the threat in normal conditions. These data demonstrate PTSD-like memory impairments in rodents and identify a potential pathophysiological mechanism of this condition.

1 CNRS UMR 5228, Centre de Neurosciences Intégratives et Cognitives, 33405 Talence, France.
2 Department of Life Science, Université de Bordeaux, 33077 Bordeaux, France.
3 INSERM U862, Neurocentre Magendie, 146 rue Leo Saignat, 33077 Bordeaux, France.
4 Institut National de la Recherche Agronomique (INRA) Centre de Tours Nouzilly, Physiologie de la Reproduction et des Comportements, CNRS UMR 6175, INRA UMR 85, Université de Tours–Haras Nationaux, 37380 Nouzilly, France.

* Present address: Institut des Maladies Neurodégénératives, CNRS UMR 5293, Universités Bordeaux 1 et 2, Avenue des Facultés, 33405 Talence, France.

{dagger} Present address: Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, CNRS UMR 5287, Universités Bordeaux 1 et 2, Avenue des Facultés, 33405 Talence, France.

{ddagger} These authors contributed equally to this work.

§ To whom correspondence should be addressed. E-mail: aline.desmedt{at}inserm.fr (A.D.); pier-vincenzo.piazza{at}inserm.fr (P.V.P.)


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ca2+ and K+ channels of normal human adrenal zona fasciculata cells: Properties and modulation by ACTH and AngII.
J. J. Enyeart and J. A. Enyeart (2013)
J. Gen. Physiol. 142, 137-155
   Abstract »    Full Text »    PDF »
Differential targeting of brain stress circuits with a selective glucocorticoid receptor modulator.
I. Zalachoras, R. Houtman, E. Atucha, R. Devos, A. M. I. Tijssen, P. Hu, P. M. Lockey, N. A. Datson, J. K. Belanoff, P. J. Lucassen, et al. (2013)
PNAS 110, 7910-7915
   Abstract »    Full Text »    PDF »
Fear, Memory, and Stress Hormones: Too Much and at the Wrong Time.
Jonathan Silver, MD and Jonathan Silver, MD (2013)
Journal Watch 2012, JP201204020000003
   Full Text »
Enhanced noradrenergic activity potentiates fear memory consolidation and reconsolidation by differentially recruiting {alpha}1- and {beta}-adrenergic receptors.
L. Gazarini, C. A. J. Stern, A. P. Carobrez, and L. J. Bertoglio (2013)
Learn. Mem. 20, 210-219
   Abstract »    Full Text »    PDF »
Perspectives on Neuroscience and Behavior.
(2012)
Neuroscientist 18, 310-311
   Full Text »    PDF »
Stress-Induced Gist-Based Memory Processing: A Possible Explanation for Overgeneralization of Fear in Posttraumatic Stress Disorder.
J. P. Oyarzun and P. A. Packard (2012)
J. Neurosci. 32, 9771-9772
   Full Text »    PDF »
Fear, Memory, and Stress Hormones: Too Much and at the Wrong Time.
(2012)
Journal Watch Psychiatry 2012, 3
   Full Text »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882