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Science 335 (6076): 1617-1621

Copyright © 2012 by the American Association for the Advancement of Science

Control of Sleep by Cyclin A and Its Regulator

Dragana Rogulja, and Michael W. Young*

Abstract: How and why the brain reversibly switches from a waking to a sleep state remain among the most intriguing questions in biology. We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and reduced the homeostatic response to sleep deprivation. CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior.

Laboratory of Genetics, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.

* To whom correspondence should be addressed. E-mail: young{at}

Small-Molecule Screen in Adult Drosophila Identifies VMAT as a Regulator of Sleep.
A. H. Nall and A. Sehgal (2013)
J. Neurosci. 33, 8534-8540
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