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Science 336 (6081): 582-585

Copyright © 2012 by the American Association for the Advancement of Science

Secreted Peptide Dilp8 Coordinates Drosophila Tissue Growth with Developmental Timing

Julien Colombani,* Ditte S. Andersen,*,{dagger} Pierre Léopold{dagger}

Abstract: Little is known about how organ growth is monitored and coordinated with the developmental timing in complex organisms. In insects, impairment of larval tissue growth delays growth and morphogenesis, revealing a coupling mechanism. We carried out a genetic screen in Drosophila to identify molecules expressed by growing tissues participating in this coupling and identified dilp8 as a gene whose silencing rescues the developmental delay induced by abnormally growing tissues. dilp8 is highly induced in conditions where growth impairment produces a developmental delay. dilp8 encodes a peptide for which expression and secretion are sufficient to delay metamorphosis without affecting tissue integrity. We propose that Dilp8 peptide is a secreted signal that coordinates the growth status of tissues with developmental timing.

Université de Nice, INSERM 1091, CNRS 7277, and France Institute of Biology, Parc Valrose, 06108 Nice, France.

* These authors contributed equally to this work.

{dagger} To whom correspondence should be addressed. E-mail: leopold{at}unice.fr (P.L.); andersen{at}unice.fr (D.S.A.)

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