Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 336 (6086): 1317-1321

Copyright © 2012 by the American Association for the Advancement of Science

Chemokine Gene Silencing in Decidual Stromal Cells Limits T Cell Access to the Maternal-Fetal Interface

Patrice Nancy,1 Elisa Tagliani,1 Chin-Siean Tay,1 Patrik Asp,2,* David E. Levy,1,2 Adrian Erlebacher1,2,{dagger}

Abstract: The chemokine-mediated recruitment of effector T cells to sites of inflammation is a central feature of the immune response. The extent to which chemokine expression levels are limited by the intrinsic developmental characteristics of a tissue has remained unexplored. We show in mice that effector T cells cannot accumulate within the decidua, the specialized stromal tissue encapsulating the fetus and placenta. Impaired accumulation was in part attributable to the epigenetic silencing of key T cell–attracting inflammatory chemokine genes in decidual stromal cells, as evidenced by promoter accrual of repressive histone marks. These findings give insight into mechanisms of fetomaternal immune tolerance, as well as reveal the epigenetic modification of tissue stromal cells as a modality for limiting effector T cell trafficking.

1 Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.
2 New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA.

* Present address: Liver Transplant Program, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USA.

{dagger} To whom correspondence should be addressed. E-mail: adrian.erlebacher{at}

VIP contribution to the decidualization program: regulatory T cell recruitment.
E. Grasso, D. Paparini, M. Aguero, G. Mor, C. Perez Leiros, and R. Ramhorst (2014)
J. Endocrinol. 221, 121-131
   Abstract »    Full Text »    PDF »
IL-33 enhances proliferation and invasiveness of decidual stromal cells by up-regulation of CCL2/CCR2 via NF-{kappa}B and ERK1/2 signaling.
W.-T. Hu, M.-Q. Li, W. Liu, L.-P. Jin, D.-J. Li, and X.-Y. Zhu (2014)
Mol. Hum. Reprod. 20, 358-372
   Abstract »    Full Text »    PDF »
Cutting Edge: Committed Th1 CD4+ T Cell Differentiation Blocks Pregnancy-Induced Foxp3 Expression with Antigen-Specific Fetal Loss.
L. Xin, J. M. Ertelt, J. H. Rowe, T. T. Jiang, J. M. Kinder, V. Chaturvedi, S. Elahi, and S. S. Way (2014)
J. Immunol. 192, 2970-2974
   Abstract »    Full Text »    PDF »
LGR4/GPR48 Inactivation Leads to Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome Defects.
T. Yi, J. Weng, S. Siwko, J. Luo, D. Li, and M. Liu (2014)
J. Biol. Chem. 289, 8767-8780
   Abstract »    Full Text »    PDF »
Fetal Intervention Increases Maternal T Cell Awareness of the Foreign Conceptus and Can Lead to Immune-Mediated Fetal Demise.
M. Wegorzewska, A. Nijagal, C. M. Wong, T. Le, N. Lescano, Q. Tang, and T. C. MacKenzie (2014)
J. Immunol. 192, 1938-1945
   Abstract »    Full Text »    PDF »
The Placenta in Toxicology. Part II: Systemic and Local Immune Adaptations in Pregnancy.
J. Svensson-Arvelund, J. Ernerudh, E. Buse, J. M. Cline, J.-D. Haeger, D. Dixon, U. R. Markert, C. Pfarrer, P. D. Vos, and M. M. Faas (2014)
Toxicol Pathol 42, 327-338
   Abstract »    Full Text »    PDF »
Interventions to improve reproductive outcomes in women with elevated natural killer cells undergoing assisted reproduction techniques: a systematic review of literature.
L. T. Polanski, M. A. P. Barbosa, W. P. Martins, M. N. Baumgarten, B. Campbell, J. Brosens, S. Quenby, and N. Raine-Fenning (2014)
Hum. Reprod. 29, 65-75
   Abstract »    Full Text »    PDF »
Regulatory T cells and the immune pathogenesis of prenatal infection.
J. H. Rowe, J. M. Ertelt, L. Xin, and S. S. Way (2013)
Reproduction 146, R191-R203
   Abstract »    Full Text »    PDF »
Development of Severe Pathology in Immunized Pregnant Mice Challenged with Lethal Malaria Parasites.
S. Mineo, M. Niikura, S.-I. Inoue, M. Kuroda, and F. Kobayashi (2013)
Infect. Immun. 81, 3865-3871
   Abstract »    Full Text »    PDF »
Maternal CD4+ and CD8+ T Cell Tolerance Towards a Fetal Minor Histocompatibility Antigen in T Cell Receptor Transgenic Mice.
A. L. Perchellet, S. Jasti, and M. G. Petroff (2013)
Biol Reprod 89, 102
   Abstract »    Full Text »    PDF »
STIM1 and STIM2-mediated Ca2+ influx regulates antitumour immunity by CD8+ T cells.
C. Weidinger, P. J. Shaw, and S. Feske (2013)
EMBO Mol Med. 5, 1311-1321
   Abstract »    Full Text »    PDF »
The motile and invasive capacity of human endometrial stromal cells: implications for normal and impaired reproductive function.
C. H. E. Weimar, N. S. Macklon, E. D. Post Uiterweer, J. J. Brosens, and B. Gellersen (2013)
Hum. Reprod. Update 19, 542-557
   Abstract »    Full Text »    PDF »
Maternal Decidual Macrophages Inhibit NK Cell Killing of Invasive Cytotrophoblasts During Human Pregnancy.
E. C. Co, M. Gormley, M. Kapidzic, D. B. Rosen, M. A. Scott, H. A. R. Stolp, M. McMaster, L. L. Lanier, A. Barcena, and S. J. Fisher (2013)
Biol Reprod 88, 155
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882