Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 338 (6106): 536-540

Copyright © 2012 by the American Association for the Advancement of Science

Elfn1 Regulates Target-Specific Release Probability at CA1-Interneuron Synapses

Emily L. Sylwestrak1,2,3, and Anirvan Ghosh1,2,*

Abstract: Although synaptic transmission may be unidirectional, the establishment of synaptic connections with specific properties can involve bidirectional signaling. Pyramidal neurons in the hippocampus form functionally distinct synapses onto two types of interneurons. Excitatory synapses onto oriens–lacunosum moleculare (O-LM) interneurons are facilitating and have a low release probability, whereas synapses onto parvalbumin interneurons are depressing and have a high release probability. Here, we show that the extracellular leucine-rich repeat fibronectin containing 1 (Elfn1) protein is selectively expressed by O-LM interneurons and regulates presynaptic release probability to direct the formation of highly facilitating pyramidal-O-LM synapses. Thus, postsynaptic expression of Elfn1 in O-LM interneurons regulates presynaptic release probability, which confers target-specific synaptic properties to pyramidal cell axons.

1 Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093–0366, USA.
2 CNS Discovery, F. Hoffmann La Roche, 4070 Basel, Switzerland.
3 Biozentrum of the University of Basel, 4056 Basel, Switzerland.

* To whom correspondence should be addressed. E-mail: anirvan.ghosh{at}roche.com


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structure of Excitatory Synapses and GABAA Receptor Localization at Inhibitory Synapses Are Regulated by Neuroplastin-65.
R. Herrera-Molina, I. Sarto-Jackson, C. Montenegro-Venegas, M. Heine, K.-H. Smalla, C. I. Seidenbecher, P. W. Beesley, E. D. Gundelfinger, and D. Montag (2014)
J. Biol. Chem. 289, 8973-8988
   Abstract »    Full Text »    PDF »
Munc18-1 redistributes in nerve terminals in an activity- and PKC-dependent manner.
T. Cijsouw, J. P. Weber, J. H. Broeke, J. A. C. Broek, D. Schut, T. Kroon, I. Saarloos, M. Verhage, and R. F. Toonen (2014)
J. Cell Biol. 204, 759-775
   Abstract »    Full Text »    PDF »
Decoding the Neuronal Tower of Babel.
C. J. McBain (2012)
Science 338, 482-483
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882