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Science 338 (6112): 1353-1356

Copyright © 2012 by the American Association for the Advancement of Science

Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain

Nikos Kyritsis,1 Caghan Kizil,1 Sara Zocher,1 Volker Kroehne,1 Jan Kaslin,1,2 Dorian Freudenreich,1 Anne Iltzsche,1 Michael Brand1,*

Abstract: The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals. Yet the signaling mechanisms initiating such a regenerative response in fish are unknown. Using cerebroventricular microinjection of immunogenic particles and immunosuppression assays, we showed that inflammation is required and sufficient for enhancing the proliferation of neural progenitors and subsequent neurogenesis by activating injury-induced molecular programs that can be observed after traumatic brain injury. We also identified cysteinyl leukotriene signaling as an essential component of inflammation in the regenerative process of the adult zebrafish brain. Thus, our results demonstrate that in zebrafish, in contrast to mammals, inflammation is a positive regulator of neuronal regeneration in the central nervous system.

1 Deutsche Forshungsgemeinschaft–Center for Regenerative Therapies Dresden (CRTD)–Cluster of Excellence, Technische Universität Dresden, Fetscherstraße 105, 01307 Dresden, Germany.
2 Australian Regenerative Medicine Institute (ARMI), Monash University, Wellington Road, Clayton, Victoria 3800, Australia.

* To whom correspondence should be addressed. E-mail: michael.brand{at}

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