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Science 343 (6170): 544-548

Copyright © 2014 by the American Association for the Advancement of Science

Drosophila Life Span and Physiology Are Modulated by Sexual Perception and Reward

Christi M. Gendron,1,* Tsung-Han Kuo,2,* Zachary M. Harvanek,1,3 Brian Y. Chung,1 Joanne Y. Yew,4,5 Herman A. Dierick,2 Scott D. Pletcher1

Abstract: Sensory perception can modulate aging and physiology across taxa. We found that perception of female sexual pheromones through a specific gustatory receptor expressed in a subset of foreleg neurons in male fruit flies, Drosophila melanogaster, rapidly and reversibly decreases fat stores, reduces resistance to starvation, and limits life span. Neurons that express the reward-mediating neuropeptide F are also required for pheromone effects. High-throughput whole-genome RNA sequencing experiments revealed a set of molecular processes that were affected by the activity of the longevity circuit, thereby identifying new candidate cell-nonautonomous aging mechanisms. Mating reversed the effects of pheromone perception; therefore, life span may be modulated through the integrated action of sensory and reward circuits, and healthy aging may be compromised when the expectations defined by sensory perception are discordant with ensuing experience.

1 Department of Molecular and Integrative Physiology and Geriatrics Center, Biomedical Sciences and Research Building, University of Michigan, Ann Arbor, MI 48109, USA.
2 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
3 Medical Scientist Training Program, Taubman Medical Library, University of Michigan, Ann Arbor, MI 48109, USA.
4 Temasek Life Sciences Laboratory, National University of Singapore, Singapore 117604.
5 Department of Biological Sciences, National University of Singapore, Singapore 117543.

* These authors contributed equally to this work.

{dagger} Corresponding author. E-mail: spletch{at}

Chemical Warfare in the Battle of the Sexes.
D. E. L. Promislow and M. Kaeberlein (2014)
Science 343, 491-492
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