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Sci. Signal., 21 October 2008
Vol. 1, Issue 42, p. pe46
[DOI: 10.1126/scisignal.142pe46]


A Scaffold Makes the Switch

Henrik G. Dohlman

Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599–7260, USA.

Abstract: Protein kinase cascades are a reoccurring feature of signal transduction pathways. Recent investigations have focused on how kinase-scaffolding proteins help to convert a graded stimulus into a switch-like or binary response. New findings reveal that the graded-to-binary conversion can be turned on or off, depending on the location of the scaffold within the cell.

* Corresponding author. E-mail, henrik_dohlman{at}

Citation: H. G. Dohlman, A Scaffold Makes the Switch. Sci. Signal. 1, pe46 (2008).

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Amplification of signaling via cellular allosteric relay and protein disorder.
B. Ma and R. Nussinov (2009)
PNAS 106, 6887-6888
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