New Targets for Acetylation in Autophagy

Ahmed Hamaï and Patrice Codogno^*

INSERM U984, University Paris-Sud 11, 92296 Châtenay-Malabry, France

Abstract: Macroautophagy is an evolutionarily conserved homeostatic process that mediates the degradation of long-lived cytoplasmic components in eukaryotes, which allows cells to survive stresses such as inflammation, hypoxia, and deprivation of nutrients or growth factors. At least 30 members of the Atg (autophagy-related) protein family orchestrate this degradative process. Additional complexity resides in the signaling networks controlling the autophagic process, which include various posttranslational modifications of key components. Evidence is accumulating that protein acetylation represents an evolutionarily conserved mechanism tightly regulating macroautophagy.

* Corresponding author. E-mail: patrice.codogno{at}u-psud.fr

The editors suggest the following Related Resources on Science sites:

In Science Signaling

EDITORS' CHOICE
Cell Biology
Acetylation and Autophagy

L. Bryan Ray (1 May 2012)
Sci. Signal. 5 (222), ec124. [DOI: 10.1126/scisignal.2003168]
 |  Abstract »

RESEARCH ARTICLES
Posttranslational Modification
Proteome-Wide Mapping of the Drosophila Acetylome Demonstrates a High Degree of Conservation of Lysine Acetylation

Brian T. Weinert, Sebastian A. Wagner, Heiko Horn, Peter Henriksen, Wenshe R. Liu, Jesper V. Olsen, Lars J. Jensen, and Chunaram Choudhary (26 July 2011)
Sci. Signal. 4 (183), ra48. [DOI: 10.1126/scisignal.2001902]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Autophagy
TRAF6 and A20 Regulate Lysine 63–Linked Ubiquitination of Beclin-1 to Control TLR4-Induced Autophagy

Chong-Shan Shi and John H. Kehrl (25 May 2010)
Sci. Signal. 3 (123), ra42. [DOI: 10.1126/scisignal.2000751]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

RESEARCH ARTICLES
Cell Biology
Ammonia Derived from Glutaminolysis Is a Diffusible Regulator of Autophagy

Christina H. Eng, Ker Yu, Judy Lucas, Eileen White, and Robert T. Abraham (27 April 2010)
Sci. Signal. 3 (119), ra31. [DOI: 10.1126/scisignal.2000911]
 |  Editor's Summary »  |  Abstract »  |  Full Text »  |  PDF »  |  Supplementary Materials »

PERSPECTIVES
Cell Biology
mTORC1 Phosphorylates the ULK1-mAtg13-FIP200 Autophagy Regulatory Complex

Edmond Y. Chan (18 August 2009)
Sci. Signal. 2 (84), pe51. [DOI: 10.1126/scisignal.284pe51]
 |  Abstract »  |  Full Text »  |  PDF »

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES: