Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 23 April 2013
Vol. 6, Issue 272, p. re2
[DOI: 10.1126/scisignal.2003832]

REVIEWS

Signaling Mechanisms in Mammalian Myoblast Fusion

Sajedah M. Hindi, Marjan M. Tajrishi, and Ashok Kumar*

Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40202, USA.

Abstract: Myoblast fusion is a critical process that contributes to the growth of muscle during development and to the regeneration of myofibers upon injury. Myoblasts fuse with each other as well as with multinucleated myotubes to enlarge the myofiber. Initial studies demonstrated that myoblast fusion requires extracellular calcium and changes in cell membrane topography and cytoskeletal organization. More recent studies have identified several cell-surface and intracellular proteins that mediate myoblast fusion. Furthermore, emerging evidence suggests that myoblast fusion is also regulated by the activation of specific cell-signaling pathways that lead to the expression of genes whose products are essential for the fusion process and for modulating the activity of molecules that are involved in cytoskeletal rearrangement. Here, we review the roles of the major signaling pathways in mammalian myoblast fusion.

* Corresponding author. E-mail: ashok.kumar{at}louisville.edu

Citation: S. M. Hindi, M. M. Tajrishi, A. Kumar, Signaling Mechanisms in Mammalian Myoblast Fusion. Sci. Signal. 6, re2 (2013).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Low-Dose Benzo(a)pyrene and Its Epoxide Metabolite Inhibit Myogenic Differentiation in Human Skeletal Muscle-Derived Progenitor Cells.
C.-Y. Chiu, Y.-P. Yen, K.-S. Tsai, R.-S. Yang, and S.-H. Liu (2014)
Toxicol. Sci. 138, 344-353
   Abstract »    Full Text »    PDF »
Activation of alternative NF-{kappa}B signaling during recovery of disuse-induced loss of muscle oxidative phenotype.
A. H. V. Remels, N. A. Pansters, H. R. Gosker, A. M. W. J. Schols, and R. C. J. Langen (2014)
Am J Physiol Endocrinol Metab 306, E615-E626
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882