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Sci. Signal., 9 April 2013
Vol. 6, Issue 270, p. pe14
[DOI: 10.1126/scisignal.2004038]

PERSPECTIVES

Turing and Wolpert Work Together During Limb Development

Takashi Miura*

Department of Anatomy and Cell Biology, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi Higashi-ku, Fukuoka 812-8582, Japan.

Abstract: Limb development has been widely studied in developmental biology. Two types of theories, one based on positional information and another based on spontaneous pattern formation, are utilized to understand this process. However, for historical reasons, these two concepts are regarded as mutually exclusive. By considering the interaction between these two mechanisms with quantitative morphological data, we can experimentally explore how the vertebrate limb skeletal pattern is established from a new direction.

* Corresponding author. E-mail: miura_t{at}anat1.med.kyushu-u.ac.jp; telephone: +81-92-6426048; fax: +81-92-6426923

Citation: T. Miura, Turing and Wolpert Work Together During Limb Development. Sci. Signal. 6, pe14 (2013).

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