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Sci. Signal., 2 April 2013
Vol. 6, Issue 269, p. pl1
[DOI: 10.1126/scisignal.2004088]


Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao1, Bülent Arman Aksoy1 , Ugur Dogrusoz2 , Gideon Dresdner1 , Benjamin Gross1 , S. Onur Sumer1 , Yichao Sun1 , Anders Jacobsen1 , Rileen Sinha1 , Erik Larsson3 , Ethan Cerami1,4 , Chris Sander1, and Nikolaus Schultz1

1 Computational Biology Center, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
2 Computer Engineering Department, Bilkent University, 06800 Ankara, Turkey.
3 Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology, University of Gothenburg, S-405 30 Gothenburg, Sweden.
4 Blueprint Medicines, Cambridge, MA 02142, USA.

Abstract: The cBioPortal for Cancer Genomics ( provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer tissues and cell lines into readily understandable genetic, epigenetic, gene expression, and proteomic events. The query interface combined with customized data storage enables researchers to interactively explore genetic alterations across samples, genes, and pathways and, when available in the underlying data, to link these to clinical outcomes. The portal provides graphical summaries of gene-level data from multiple platforms, network visualization and analysis, survival analysis, patient-centric queries, and software programmatic access. The intuitive Web interface of the portal makes complex cancer genomics profiles accessible to researchers and clinicians without requiring bioinformatics expertise, thus facilitating biological discoveries. Here, we provide a practical guide to the analysis and visualization features of the cBioPortal for Cancer Genomics.

Correspondence should be addressed to cbioportal{at}; user support is available at cbioportal{at}

Citation: J. Gao, B. A. Aksoy, U. Dogrusoz, G. Dresdner, B. Gross, S. O. Sumer, Y. Sun, A. Jacobsen, R. Sinha, E. Larsson, E. Cerami, C. Sander, N. Schultz, Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal. Sci. Signal. 6, pl1 (2013).

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