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Sci. Signal., 14 May 2013
Vol. 6, Issue 275, p. pe18
[DOI: 10.1126/scisignal.2004259]

PERSPECTIVES

A Role for Hipk in the Hippo Pathway

Emad Heidary Arash and Liliana Attisano*

Department of Biochemistry and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.

Abstract: Since characterization of the Hippo pathway as a major regulator of growth control and organ size, major efforts to unravel the molecular mechanisms that regulate this pathway have been undertaken. These investigations have led to the discovery of diverse upstream regulators of Hippo signaling, the majority of which function to activate the Hippo kinase cascade and thereby restrict the transcriptional output of the downstream targets, Yorkie (Yki) in flies and TAZ and YAP in mammals, collectively Yki/TAZ/YAP. Two studies have delineated a role for HIPK (homeodomain-interacting protein kinase) in promoting Yki/TAZ/YAP transcriptional activity.

* Corresponding author. E-mail: liliana.attisano{at}utoronto.ca

Citation: E. Heidary Arash, L. Attisano, A Role for Hipk in the Hippo Pathway. Sci. Signal. 6, pe18 (2013).

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