Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 18 March 2008
Vol. 1, Issue 11, p. ec106
[DOI: 10.1126/stke.111ec106]

EDITORS' CHOICE

Medicine Stress Relief in Alcoholism

Paula A. Kiberstis

Science, AAAS, Washington, DC 20005, USA

Despite the success of psychosocial interventions such as Alcoholics Anonymous, chronic alcohol abuse remains a significant public health problem. Noting that stress is a relapse trigger in alcoholism, George et al. explored whether pharmacological inhibition of the neurokinin 1 receptor (NK1R), a mediator of the brain’s stress response, would alleviate symptoms associated with alcohol dependence. Mice genetically deficient in NK1R consumed less alcohol than controls. A drug that antagonizes NK1R was used in a small, controlled study of recently detoxified alcoholic inpatients and showed promising activity, such as reducing alcohol cravings. However, these latter results need to be confirmed in much larger, longer-term studies.

D. T. George, J. Gilman, J. Hersh, A. Thorsell, D. Herion, C. Geyer, X. Peng, W. Kielbasa, R. Rawlings, J. E. Brandt, D. R. Gehlert, J. T. Tauscher, S. P. Hunt, D. Hommer, M. Heilig, Neurokinin 1 receptor antagonism as a possible therapy for alcoholism. Science 319, 1536-1539 (2008). [Abstract] [Full Text]

Citation: P. A. Kiberstis, Stress Relief in Alcoholism. Sci. Signal. 1, ec106 (2008).


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882