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Sci. Signal., 1 April 2008
Vol. 1, Issue 13, p. eg3
[DOI: 10.1126/stke.113eg3]

EDITORIAL GUIDES

Focus Issue: Mechanisms of Gene Regulation

John F. Foley*

Associate Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.

Abstract: In this Focus Issue of Science Signaling, which complements the Science Special Issue on Gene Regulation (http://www.sciencemag.org/generegulation/), we examine the multilayered mechanisms that control how gene expression is turned on or off. Perspectives in this issue discuss how oncogenic Ras directs the silencing of tumor suppressor genes; how intrachromosomal looping brings enhancers and promoters together to stimulate gene expression; and how the abundance of a transcriptional coactivator affects nuclear receptor–mediated transcription.

*Corresponding author. E-mail: jfoley{at}aaas.org

Citation: J. F. Foley, Focus Issue: Mechanisms of Gene Regulation. Sci. Signal. 1, eg3 (2008).

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882