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Sci. Signal., 15 April 2008
Vol. 1, Issue 15, p. ec131
[DOI: 10.1126/stke.115ec131]


Neuroscience Keeping Axons on Track

Pamela J. Hines

Science, AAAS, Washington, DC 20005, USA

Like cars on a highway, neuronal signaling routes merge and diverge between origin and destination. By identifying developing motor and sensory neurons in the mouse embryo with distinguishable labels, Gallarda et al. (see the Perspective by Murai and Pasquale) have visualized how the growing axons keep entanglement at bay. The axons grew into parallel but separated bundles. Signaling through the ephrin A receptors and ligands present on the growing axons served to keep like axons bundled with like.

B. W. Gallarda, D. Bonanomi, D. Müller, A. Brown, W. A. Alaynick, S. E. Andrews, G. Lemke, S. L. Pfaff, T. Marquardt, Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling. Science 320, 233-236 (2008). [Abstract] [Full Text]

K. K. Murai, E. B. Pasquale, Axons seek neighborly advice. Science 320, 185-186 (2008). [Summary] [Full Text]

Citation: P. J. Hines, Keeping Axons on Track. Sci. Signal. 1, ec131 (2008).

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