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Sci. Signal., 29 April 2008
Vol. 1, Issue 17, p. pe17
[DOI: 10.1126/stke.117pe17]


Notch Signaling in Osteoblasts

Ernesto Canalis*

Department of Research, Saint Francis Hospital and Medical Center, 114 Woodland Street, Hartford, CT 06105, USA, and University of Connecticut School of Medicine, Farmington, CT 06030, USA.

Abstract: Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone. Notch proteins are single-pass transmembrane receptors that determine cell fate. Recent gain-of-function and loss-of-function experiments reveal a suppressive effect of Notch in osteoblast and osteoclast differentiation in development and in the postnatal bone, which establishes a role for Notch signaling in bone remodeling.

*Corresponding author. E-mail, ecanalis{at}

Citation: E. Canalis, Notch Signaling in Osteoblasts. Sci. Signal. 1, pe17 (2008).

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