Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 13 May 2008
Vol. 1, Issue 19, p. ec180
[DOI: 10.1126/stke.119ec180]


Cell Biology Wholesale Heat Shock

L. Bryan Ray

Science, Science Signaling, AAAS, Washington, DC 20005, USA

Exposure to increased temperature can damage cells, and individual cells respond to heat shock by synthesizing protective chaperone proteins that help maintain proper protein folding. Prahlad et al. report experiments in the nematode Caenorhabditis elegans that show an organism-wide, rather than cell-autonomous, response to heat shock. Synthesis of heat shock proteins was inhibited in animals carrying mutations that disrupt the function of a sensory neuron previously known to respond to increased temperature and influence behavior. The heat shock response was also altered in response to dauer pheromone, which regulates growth and metabolism. Thus, C. elegans appears to possess a regulatory system that coordinates the organismal heat shock response with multiple environmental cues.

V. Prahlad, T. Cornelius, R. I. Morimoto, Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science 320, 811-814 (2008). [Abstract] [Full Text]

Citation: L. B. Ray, Wholesale Heat Shock. Sci. Signal. 1, ec180 (2008).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882