Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Sci. Signal., 13 May 2008
Vol. 1, Issue 19, p. pe21
[DOI: 10.1126/stke.119pe21]

PERSPECTIVES

TCR Triggering by the pMHC Complex: Valency, Affinity, and Dynamics

Rajat Varma*

Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Bethesda, MD 20892, USA.

Abstract: The interaction between the T cell receptor (TCR) and a peptide-loaded major histocompatibility complex (pMHC) is one of the most-studied interactions in immunology, and yet the precise mechanism by which this system operates is still not fully understood. One key issue is whether TCR triggering minimally requires monomeric pMHC complexes or higher-order multimers (two or more pMHCs). Any model of TCR triggering must explain the high sensitivity, specificity, and dynamic range of ligand responsiveness that this receptor system exhibits. Most models of TCR triggering have not fully appreciated the dynamic aspects of TCR triggering. TCR triggering happens very quickly, and the properties of sensitivity and specificity can be explained by a model that accounts for the interaction dynamics of such a receptor system. In this paper, it is proposed that the important parameter in TCR triggering is the immobilization of the TCR-pMHC complex in the plasma membrane. Whether this involves monomeric or multimeric pMHCs may depend on the affinity of the TCR for the pMHC.

*Contact information. E-mail, varmarajat{at}mail.nih.gov

Citation: R. Varma, TCR Triggering by the pMHC Complex: Valency, Affinity, and Dynamics. Sci. Signal. 1, pe21 (2008).

Read the Full Text


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Hematopoietic Lineage Cell-Specific Protein 1 Is Recruited to the Immunological Synapse by IL-2-Inducible T Cell Kinase and Regulates Phospholipase C{gamma}1 Microcluster Dynamics during T Cell Spreading.
E. Carrizosa, T. S. Gomez, C. M. Labno, D. A. Klos Dehring, X. Liu, B. D. Freedman, D. D. Billadeau, and J. K. Burkhardt (2009)
J. Immunol. 183, 7352-7361
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 16 December 2008.
J. F. Foley and A. M. VanHook (2008)
Science Signaling 1, pc14
   Abstract »    Full Text »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882